2,2-DIPHENYLETHYLISOCYANIDE

Base Information

• Chemical Name: 2,2-DIPHENYLETHYLISOCYANIDE
• CAS No.: 374081-26-2
• Molecular Formula: C15H13N
• Molecular Weight: 207.275
• Hs Code.: 2926909090
• Mol file: 374081-26-2.mol

Synonyms:2,2-DIPHENYLETHYLISOCYANIDE

Chemical Property of 2,2-DIPHENYLETHYLISOCYANIDE

Chemical Property:

• PSA: 0.00000
• LogP: 2.96850

Purity/Quality:

99% ^*data from raw suppliers

2,2-Diphenylethylisocyanide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,2-DIPHENYLETHYLISOCYANIDE

There total 3 articles about 2,2-DIPHENYLETHYLISOCYANIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

N-(β-Diphenylethyl)formamid (19501-33-8) → (2-isocyanoethane-1,1-diyl)dibenzene (374081-26-2)

Guidance literature:

With triethylamine; trichlorophosphate; In dichloromethane; for 0.0666667h; Cooling with ice; Green chemistry;

DOI:10.1039/d0gc02722g

Reference yield:

2-Benzoylbenzoic acid (85-52-9) + histamine (51-45-6) → (2-isocyanoethane-1,1-diyl)dibenzene (374081-26-2)

Guidance literature:

With benzaldehyde; In methanol;

Reference yield:

2,2-Diphenylethylamine (3963-62-0) → (2-isocyanoethane-1,1-diyl)dibenzene (374081-26-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: Reflux

2.1: trichlorophosphate; diisopropylamine / dichloromethane / 1 h / Cooling with ice

2.2: 1 h

With diisopropylamine; trichlorophosphate; In dichloromethane;

upstream raw materials:

2-Benzoylbenzoic acid

histamine

2,2-Diphenylethylamine

N-(β-Diphenylethyl)formamid

Downstream raw materials:

2-benzoyl-N-[(2,2-diphenyl-ethylcarbamoyl)-phenyl-methyl]-N-[2-(1H-imidazol-4-yl)-ethyl]-benzamide

Refernces

• 1、 Ahmadian-Moghaddam, Maryam,D?mling, Alexander,Patil, Pravin. "Isocyanide 2.0". supporting information. p. 6902 - 6911. Retrieved 2020/11/09.
• 2、 -. "Modulators of TNF-alpha signaling". . . Retrieved 2008/06/13.