Carbamic acid, (2-fluorocyclopropyl)-, 1,1-dimethylethyl ester, (1S-trans)- (9CI)

Base Information

• Chemical Name: Carbamic acid, (2-fluorocyclopropyl)-, 1,1-dimethylethyl ester, (1S-trans)- (9CI)
• CAS No.: 167073-09-8
• Molecular Formula: C₈H₁₄FNO₂
• Molecular Weight: 175.203
• Mol file: 167073-09-8.mol

Synonyms:Carbamic acid, (2-fluorocyclopropyl)-, 1,1-dimethylethyl ester, (1S-trans)- (9CI)

Chemical Property of Carbamic acid, (2-fluorocyclopropyl)-, 1,1-dimethylethyl ester, (1S-trans)- (9CI)

Chemical Property:

Purity/Quality:

99%+, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of Carbamic acid, (2-fluorocyclopropyl)-, 1,1-dimethylethyl ester, (1S-trans)- (9CI)

There total 14 articles about Carbamic acid, (2-fluorocyclopropyl)-, 1,1-dimethylethyl ester, (1S-trans)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

C14H18FNO4S → tert-butyl N-<(1R,2S)-2-fluorocyclopropyl>carbamate (127199-16-0,167073-09-8)

Guidance literature:

With magnesium; In methanol; at 4 - 20 ℃; for 3h;

Reference yield: 78.0%

di-tert-butyl dicarbonate (24424-99-5) + (1R*,2S*)-2-fluorocyclopropylamine hydrochloride (114152-95-3,114152-96-4,141042-20-8,141042-21-9,143062-71-9,143062-74-2,143062-85-5) → tert-butyl dl-N-(cis-2-fluorocyclopropyl)carbamate (105919-35-5,127199-15-9,127199-16-0,142977-47-7,143022-91-7,143840-33-9,146726-40-1,167073-09-8)

Guidance literature:

With triethylamine; In dichloromethane; at 0 ℃; for 2h;

DOI:10.1016/S0040-4020(01)89665-4

Reference yield: 73.0%

(1S,2R)-2-Fluoro-cyclopropanecarboxylic acid + tert-butyl alcohol (75-65-0) → ((1R,2R)-2-Fluoro-cyclopropyl)-carbamic acid tert-butyl ester (167073-09-8)

Guidance literature:

With diphenyl phosphoryl azide; triethylamine; for 4.5h;

DOI:10.1021/jm00046a019

upstream raw materials:

di-tert-butyl dicarbonate

(1R,2R)-2-fluorocyclopropylamine hydrochloride

(-)-cis-2-fluorocyclopropylamine hydrochloride

(1S,2S)-2-fluorocyclopropane-1-carboxylic acid

Downstream raw materials:

(1S,2R)-2-fluorocyclopropylammonium p-toluenesulfonate

(1R,2S)-2-fluorocyclopropylamine p-toluenesulfonic acid salt

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