1-Allyl-2-aminomethylpyrrolidine

Base Information

• Chemical Name: 1-Allyl-2-aminomethylpyrrolidine
• CAS No.: 66411-51-6
• Molecular Formula: C8H16N2
• Molecular Weight: 140.22604
• Hs Code.: 2933990090
• Mol file: 66411-51-6.mol

Synonyms:1-Allyl-2-aminomethylpyrrolidine;N-ALLYL-2-(AMINOMETHYL)PYRROLIDINE;N-ALLYL-2-(AMINOMETHYL)PYRROLIDNE;[1-(prop-2-en-1-yl)pyrrolidin-2-yl]MethanaMine;(2S)-1-(2-propen-1-yl)-2-PyrrolidineMethanaMine;(1-Allylpyrrolidin-2-yl)MethanaMine

Chemical Property of 1-Allyl-2-aminomethylpyrrolidine

Chemical Property:

• Vapor Pressure: 0.112mmHg at 25°C
• Boiling Point: 220.6°C at 760 mmHg
• PKA: 9.91±0.29(Predicted)
• Flash Point: 78.9°C
• PSA: 29.26000
• Density: 0.953g/cm³
• LogP: 1.23370
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

98%min ^*data from raw suppliers

1-Allyl-2-aminomethylpyrrolidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Allyl-2-aminomethylpyrrolidine

There total 4 articles about 1-Allyl-2-aminomethylpyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

(-)-(S)-1-allyl-2-pyrrolidinecarboxamide (114812-43-0) → 1-[(S)-1-allylpyrrolidin-2-yl]methanamine (66411-51-6)

Guidance literature:

With diisobutylaluminium hydride; In tetrahydrofuran;

DOI:10.3390/molecules16097458

Reference yield:

sodium bis(2-methoxyethoxy)aluminum dihydride + ethanol (64-17-5) + (-)-(S)-1-allyl-2-pyrrolidinecarboxamide (114812-43-0) → 1-[(S)-1-allylpyrrolidin-2-yl]methanamine (66411-51-6)

Guidance literature:

With hydrogenchloride; sodium hydroxide; In tetrahydrofuran; toluene;

Reference yield:

allyl (S)-1-allylpyrrolidine-2-carboxylate (114812-37-2) → 1-[(S)-1-allylpyrrolidin-2-yl]methanamine (66411-51-6)

Guidance literature:

Multi-step reaction with 2 steps

1: NH₃; NaCN / methanol

2: SDMA / toluene

With sodium cyanide; ammonia; In methanol; toluene; 1: Substitution / 2: Reduction;

upstream raw materials:

(-)-(S)-1-allyl-2-pyrrolidinecarboxamide

allyl (S)-1-allylpyrrolidine-2-carboxylate

L-proline

ethanol

Downstream raw materials:

(S)-N-[(1-allyl-2-pyrrolidinyl)methyl]-2-hydroxy-3-methoxy-5-(3'-fluoropropyl)benzamide

(S)-N-[(1-allyl-2-pyrrolidinyl)methyl]-3-methoxy-2-[(2-methoxyethoxy)methoxy]-5-(3-fluoropropyl)benzamide

3-(3-(((S)-1-allylpyrrolidin-2-yl)methylcarbamoyl)-4-methoxyphenyl)propyl-4-methylbenzenesulfonate

C₂₃H₃₇⁽¹⁸⁾FN₂OSi

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