1-(4-Chlorophenyl)-2-(3,4-difluorophenyl)ethanone

Base Information

• Chemical Name: 1-(4-Chlorophenyl)-2-(3,4-difluorophenyl)ethanone
• CAS No.: 1373156-53-6
• Molecular Formula: C14H9ClF2O
• Molecular Weight: 266.675
• Hs Code.: 2914790090
• Mol file: 1373156-53-6.mol

Synonyms:1-(4-Chlorophenyl)-2-(3,4-difluorophenyl)ethanone;4'-Chloro-2-(3,4-difluorophenyl)acetophenone

Chemical Property of 1-(4-Chlorophenyl)-2-(3,4-difluorophenyl)ethanone

Chemical Property:

• PSA: 17.07000
• LogP: 4.04360

Purity/Quality:

97% ^*data from raw suppliers

4'-Chloro-2-(3,4-difluorophenyl)acetophenone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(4-Chlorophenyl)-2-(3,4-difluorophenyl)ethanone

There total 3 articles about 1-(4-Chlorophenyl)-2-(3,4-difluorophenyl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

chlorobenzene (108-90-7) + 3,4-difluorophenylacetyl chloride (121639-61-0) → C14H9ClF2O (1373156-53-6)

Guidance literature:

With aluminum (III) chloride; at 0 - 20 ℃; for 8.5h;

DOI:10.1016/j.bioorg.2021.105268

Reference yield:

(3,4-difluorophenyl)acetic acid (658-93-5) → C14H9ClF2O (1373156-53-6)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine; 1,1'-carbonyldiimidazole / dichloromethane / 6 h / 25 °C

2: diethyl ether / 4 h / 0 - 5 °C

With triethylamine; 1,1'-carbonyldiimidazole; In diethyl ether; dichloromethane;

DOI:10.1016/j.bmcl.2012.02.070

Reference yield:

2-(3,4-difluorophenyl)-N-methoxy-N-methylacetamide (946402-25-1) + (4-chlorphenyl)magnesium bromide (873-77-8) → C14H9ClF2O (1373156-53-6)

Guidance literature:

In diethyl ether; at 0 - 5 ℃; for 4h;

DOI:10.1016/j.bmcl.2012.02.070

upstream raw materials:

2-(3,4-difluorophenyl)-N-methoxy-N-methylacetamide

(4-chlorphenyl)magnesium bromide

(3,4-difluorophenyl)acetic acid

chlorobenzene

Downstream raw materials:

C₂₇H₂₀ClF₂NO₄

3-[4-[3-(4-chlorophenyl)-2-(3,4-difluorophenyl)-3-oxo-propyl]phenyl]isoxazole-5-carboxylic acid

C₂₇H₂₀ClF₂NO₃S

C₂₅H₁₆ClF₂NO₃S

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