7-O-DeMethyl α-Narcotine

Base Information

Chemical Name:7-O-DeMethyl α-Narcotine
CAS No.:68353-55-9
Molecular Formula:C21H21NO7
Molecular Weight:399.4
Hs Code.:
Mol file:68353-55-9.mol

Synonyms:7-O-DeMethyl α-Narcotine

Suppliers and Price of 7-O-DeMethyl α-Narcotine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
7-O-Demethylα-Narcotine
100mg
$ 1190.00

American Custom Chemicals Corporation
7-ORTHO-DESMETHYLNOSCAPINE 95.00%
5MG
$ 495.04

Total 3 raw suppliers

Chemical Property of 7-O-DeMethyl α-Narcotine

Chemical Property:

PSA：86.69000
LogP:2.51670
Storage Temp.:-20°C Freezer, Under inert atmosphere
Solubility.:Dichloromethane (Slightly), DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

99% ^*data from raw suppliers

7-O-Demethylα-Narcotine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses 7-O-Demethyl α-Narcotine, is a derivative of Narcotine (N378890), a noscapinoid class of microtubule binding compounds that alter microtubule dynamics without affecting tubulin polymer mass. Noscapinoids show great promise as chemotherapeutic agents for the treatment of human cancers. Unlike Narcotine, (-)-α-Narcotinediol deos not inhibit small-intestinal transport in rats.

Technology Process of 7-O-DeMethyl α-Narcotine

There total 4 articles about 7-O-DeMethyl α-Narcotine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 128-62-1
noscapine

: 68353-55-9
(S)-7-hydroxy-6-methoxy-3-((R)-4-methoxy-6-methyl-5,6,7,8-tetrahydro[1,3]dioxolo-[4,5-g]isoquinolin-5-yl)isobenzofuran-1(3H)-one

Guidance literature:: With sodium azide; sodium iodide; In N,N-dimethyl-formamide; at 140 ℃; for 4h; regioselective reaction; Inert atmosphere;
DOI:10.1016/j.bcp.2011.03.029

Reference yield:

: 851983-58-9
5-methoxy-3-(4-methoxy-6-methyl-5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-g]isoquinolin-5-yl)-3-oxo-1,3-dihydro-isobenzofuran-4-yl

: 100-46-9
benzylamine

: 870190-27-5
7-benzylamino-6-methoxy-3-(4-methoxy-6-methyl-5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-g]isoquinolin-5-yl)-3H-isobenzofuran-1-one

: 68353-55-9
(S)-7-hydroxy-6-methoxy-3-((R)-4-methoxy-6-methyl-5,6,7,8-tetrahydro[1,3]dioxolo-[4,5-g]isoquinolin-5-yl)isobenzofuran-1(3H)-one

Guidance literature:: With barium dihydroxide; 2-(2^'-di-tert-butylphosphine)biphenylpalladium(II) acetate; α,α,α-trifluorotoluene; In water; at 110 ℃; for 0.25h;
DOI:10.1021/jm050674q