2-(TETRAHYDROFURAN-3-YL)MALONICACID

Base Information

• Chemical Name: 2-(TETRAHYDROFURAN-3-YL)MALONICACID
• CAS No.: 1354951-08-8
• Molecular Formula: C₇H₁₀O₅
• Molecular Weight: 174.153
• Mol file: 1354951-08-8.mol

Synonyms:2-(TETRAHYDROFURAN-3-YL)MALONICACID

Chemical Property of 2-(TETRAHYDROFURAN-3-YL)MALONICACID

Chemical Property:

Purity/Quality:

99%min ^*data from raw suppliers

2-(tetrahydrofuran-3-yl)malonicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(TETRAHYDROFURAN-3-YL)MALONICACID

There total 2 articles about 2-(TETRAHYDROFURAN-3-YL)MALONICACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

diethyl (3(S)-tetrahydrofuranyl)malonate (146255-23-4) → (S)-2-(Tetrahydro-furan-3-yl)-malonic acid (1354951-08-8)

Guidance literature:

With sodium hydroxide; In ethanol; for 48h;

DOI:10.1021/ja00055a069

Reference yield:

diethyl (3(R)-tetrahydrofuranyl)malonate (146255-22-3) → (R)-2-(Tetrahydro-furan-3-yl)-malonic acid (1354951-08-8)

Guidance literature:

With sodium hydroxide; In ethanol; for 48h;

DOI:10.1021/ja00055a069

Reference yield:

(S)-2-(Tetrahydro-furan-3-yl)-malonic acid (1354951-08-8) → (2(S)-tetrahydrofuranyl)acetic acid (146255-26-7)

Guidance literature:

With copper(I) oxide; In acetonitrile; at 80 ℃; for 6h; Yield given;

DOI:10.1021/ja00055a069

upstream raw materials:

diethyl (3(S)-tetrahydrofuranyl)malonate

diethyl (3(R)-tetrahydrofuranyl)malonate

Downstream raw materials:

(2(S)-tetrahydrofuranyl)acetic acid

Refernces

• 1、 Thompson, Wayne J.,Ghosh, Arun K.,Katharine Holloway,Lee, Hee Yoon,Munson, Peter M.,Schwering, John E.,Wai, Jenny,Darke, Paul L.,Zugay, Joan,Emini, Emilio A.,Schleif, William A.,Huff, Joel R.,Anderson, Paul S.. "3′-tetrahydrofuranylglycine as a novel, unnatural amino acid surrogate for asparagine in the design of inhibitors of the HIV protease". . p. 801 - 803. Retrieved 2007/10/02.