(S)-2-(Tetrahydrofuran-3-YL)acetic acid

Base Information

Chemical Name:(S)-2-(Tetrahydrofuran-3-YL)acetic acid
CAS No.:146255-26-7
Molecular Formula:C₆H₁₀O₃
Molecular Weight:130.144
Hs Code.:
DSSTox Substance ID:DTXSID70566148
Wikidata:Q82451620

Synonyms:(S)-2-(TETRAHYDROFURAN-3-YL)ACETIC ACID;146255-26-7;3-Furanacetic acid, tetrahydro-, (3S)-;2-[(3s)-oxolan-3-yl]acetic acid;(S)-2-(Tetrahydrofuran-3-yl)aceticacid;MFCD19229760;SCHEMBL1691652;DTXSID70566148;[(3S)-Oxolan-3-yl]acetic acid;AKOS027339076;AS-38910;CS-0155206;Z1205496111

Suppliers and Price of (S)-2-(Tetrahydrofuran-3-YL)acetic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(S)-2-(Tetrahydrofuran-3-yl)aceticAcid
10mg
$ 45.00

Crysdot
(S)-2-(Tetrahydrofuran-3-yl)aceticacid 97%
1g
$ 575.00

Ambeed
(S)-2-(Tetrahydrofuran-3-yl)aceticacid 97%
100mg
$ 112.00

Ambeed
(S)-2-(Tetrahydrofuran-3-yl)aceticacid 97%
250mg
$ 216.00

Ambeed
(S)-2-(Tetrahydrofuran-3-yl)aceticacid 97%
1g
$ 539.00

Alichem
(S)-2-(Tetrahydrofuran-3-yl)aceticacid
1g
$ 654.90

Alichem
(S)-2-(Tetrahydrofuran-3-yl)aceticacid
5g
$ 1877.26

AK Scientific
(S)-2-(Tetrahydrofuran-3-YL)aceticacid
1g
$ 787.00

AK Scientific
(S)-2-(Tetrahydrofuran-3-YL)aceticacid
250mg
$ 351.00

AK Scientific
(S)-2-(Tetrahydrofuran-3-YL)aceticacid
100mg
$ 211.00

Total 6 raw suppliers

Chemical Property of (S)-2-(Tetrahydrofuran-3-YL)acetic acid

Chemical Property:

XLogP3:0
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:130.062994177
Heavy Atom Count:9
Complexity:111

Purity/Quality:

97% ^*data from raw suppliers

(S)-2-(Tetrahydrofuran-3-yl)aceticAcid ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1COCC1CC(=O)O
Isomeric SMILES:C1COC[C@@H]1CC(=O)O

Technology Process of (S)-2-(Tetrahydrofuran-3-YL)acetic acid

There total 2 articles about (S)-2-(Tetrahydrofuran-3-YL)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1354951-08-8
(S)-2-(Tetrahydro-furan-3-yl)-malonic acid

: 146255-26-7
(2(S)-tetrahydrofuranyl)acetic acid

Guidance literature:: With copper(I) oxide; In acetonitrile; at 80 ℃; for 6h; Yield given;
DOI:10.1021/ja00055a069

Reference yield:

: 146255-23-4
diethyl (3(S)-tetrahydrofuranyl)malonate

: 146255-26-7
(2(S)-tetrahydrofuranyl)acetic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 1N aq. NaOH / ethanol / 48 h / Ambient temperature

2: 16.85 g / Cu₂O / acetonitrile / 6 h / 80 °C

With copper(I) oxide; sodium hydroxide; In ethanol; acetonitrile;
DOI:10.1021/jm00068a006

Reference yield:

: 146255-26-7
(2(S)-tetrahydrofuranyl)acetic acid

: N-tert-butyl-2-<2(R)-hydroxy-4-phenyl-3(S)-((N-(2-quinolylcarbonyl)-2(S)-(3(S)-tetrahydrofuranyl)glycinyl)amino)butyl>decahydro-(4aS,8aS) isoquinoline-3(S)-carboxamide

Guidance literature:: Multi-step reaction with 7 steps

1: triethylamine / tetrahydrofuran / 0.58 h / -15 - 0 °C

2: 1.) n-butyllithium / 1.) THF, hexane, - 60 deg C, 2.) THF, hexane, -78 deg C, 1 h

3: 1.) potassium bis(trimethylsilyl)amide, 2.) 2,4,6-triisopropylbenzenesulfonyl azide / 1.) THF, toluene, -78 deg C, 30 min, 2.) THF, toluene, -75 deg C, 2 min

4: aq. LiOH / tetrahydrofuran / 0.75 h / Ambient temperature

5: 0.132 g / 1-hydroxybenzotriazole hydrate, 1-ethyl-3-(3-(dimethylamino)propyl)carbodiimide hydrochloride, 4-methylmorpholine / dimethylformamide / 4 h

6: 0.12 g / H₂ / 5percent Pd/C / tetrahydrofuran; methanol / 12 h

7: Et₃N / tetrahydrofuran / 3 h / Ambient temperature

With 4-methyl-morpholine; lithium hydroxide; n-butyllithium; 2,4,6-Triisopropylbenzenesulfonyl azide; hydrogen; potassium hexamethylsilazane; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00068a006