6-Chloroquinoline-2-carbaldehyde

Base Information

• Chemical Name: 6-Chloroquinoline-2-carbaldehyde
• CAS No.: 59394-26-2
• Molecular Formula: C10H6ClNO
• Molecular Weight: 191.617
• Hs Code.: 2933499090
• NSC Number: 114749
• DSSTox Substance ID: DTXSID00297216
• Nikkaji Number: J3.555.607I
• Wikidata: Q82038222
• Mol file: 59394-26-2.mol

Synonyms:6-chloroquinoline-2-carbaldehyde;59394-26-2;6-Chlorochinoline-2-aldehyde;6-chloro-2-quinolinecarbaldehyde;MFCD06824184;6-Chloro-2-quinolinecarboxaldehyde;NSC114749;SCHEMBL3597858;DTXSID00297216;MDISQESZDBPYRY-UHFFFAOYSA-N;6-Chloro-quinoline-2-carbaldehyde;AKOS006238119;NSC-114749;SB67599;NS-01812;6-chloroquinoline-2-carbaldehyde, AldrichCPR;CS-0021483;FT-0730931

Chemical Property of 6-Chloroquinoline-2-carbaldehyde

Chemical Property:

• Vapor Pressure: 4.76E-05mmHg at 25°C
• Melting Point: 140 °C(Solv: ligroine (8032-32-4))
• Boiling Point: 349.3°Cat760mmHg
• PKA: 2.85±0.43(Predicted)
• Flash Point: 165°C
• PSA: 29.96000
• Density: 1.364g/cm³
• LogP: 2.70070
• XLogP3: 2.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 191.0137915
• Heavy Atom Count: 13
• Complexity: 197

Purity/Quality:

97% ^*data from raw suppliers

6-Chloro-2-quinolinecarboxaldehyde ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC2=C(C=CC(=N2)C=O)C=C1Cl
• Uses: 6-Chloro-2-quinolinecarboxaldehyde acts as a reagent for the design, synthesis and biological evaluation of 2-substituted quinoline library of potential antileishmanial agents. Synthesis and biological evaluation of quinoline derivative as HDAC class I inhibitors.

Technology Process of 6-Chloroquinoline-2-carbaldehyde

There total 6 articles about 6-Chloroquinoline-2-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

6-chloro-2-methylquinoline (92-46-6) → 6-chloroquinoline-2-carbaldehyde (59394-26-2)

Guidance literature:

With selenium(IV) oxide; In 1,4-dioxane; for 1.5h; Reflux;

DOI:10.1016/j.tet.2013.07.033

Reference yield:

6-chloro-2-methyl-quinolin-4-ol (15644-86-7) → 6-chloroquinoline-2-carbaldehyde (59394-26-2)

Guidance literature:

Multi-step reaction with 3 steps

1: phosphorus tribromide / N,N-dimethyl-formamide / 3 h / 0 - 20 °C

2: n-butyllithium / tetrahydrofuran / 0.5 h / -78 °C

3: selenium(IV) oxide / 1,4-dioxane / 2 h / 80 °C

With selenium(IV) oxide; n-butyllithium; phosphorus tribromide; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide;

DOI:10.1016/j.ejmech.2013.08.028

Reference yield:

4-chloro-aniline (106-47-8) → 6-chloroquinoline-2-carbaldehyde (59394-26-2)

Guidance literature:

Multi-step reaction with 4 steps

1: polyphosphoric acid / 16.75 h / 80 - 120 °C

2: phosphorus tribromide / N,N-dimethyl-formamide / 3 h / 0 - 20 °C

3: n-butyllithium / tetrahydrofuran / 0.5 h / -78 °C

4: selenium(IV) oxide / 1,4-dioxane / 2 h / 80 °C

With selenium(IV) oxide; n-butyllithium; phosphorus tribromide; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide;

DOI:10.1016/j.ejmech.2013.08.028

upstream raw materials:

6-chloro-2-methylquinoline

4-chloro-aniline

6-chloro-2-methyl-quinolin-4-ol

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 59394-26-2 6-chloroquinoline-2-carbaldehyde

Send

Send

Metric Ton KG G Pound L ML

Send

Send