3-isopropylpiperidine(SALTDATA: FREE)

Base Information

• Chemical Name: 3-isopropylpiperidine(SALTDATA: FREE)
• CAS No.: 13603-18-4
• Molecular Formula: C₈H₁₇N
• Molecular Weight: 127.23
• Mol file: 13603-18-4.mol

Synonyms:3-isopropylpiperidine(SALTDATA: FREE)

Chemical Property of 3-isopropylpiperidine(SALTDATA: FREE)

Chemical Property:

• Melting Point: 133-134 °C
• Boiling Point: 165.6±8.0 °C(Predicted)
• PKA: 10.41±0.10(Predicted)
• PSA: 12.03000
• Density: 0.822±0.06 g/cm3(Predicted)
• LogP: 1.97080

Purity/Quality:

95-99% ^*data from raw suppliers

3-(propan-2-yl)piperidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-isopropylpiperidine(SALTDATA: FREE)

There total 6 articles about 3-isopropylpiperidine(SALTDATA: FREE) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

2-(2-bromopyridin-3-yl)propan-2-ol (909532-39-4) → 3-isopropylpiperidine (13603-18-4)

Guidance literature:

With hydrogenchloride; palladium 10% on activated carbon; hydrogen; In methanol; water; at 85 ℃; for 64h; under 30003 Torr; Autoclave;

DOI:10.1055/s-0034-1379502

Reference yield: 78.0%

2-(2-chloropyridin-3-yl)propan-2-ol (267003-35-0) → 3-isopropylpiperidine (13603-18-4)

Guidance literature:

With hydrogenchloride; palladium 10% on activated carbon; hydrogen; In methanol; water; at 50 ℃; under 38002.6 Torr; Autoclave;

DOI:10.1002/ejoc.201900450

Reference yield:

2-chloropyridine (109-09-1) → 3-isopropylpiperidine (13603-18-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / 0.28 h / -50 °C

1.2: 8 h / -50 - 20 °C / Inert atmosphere

2.1: palladium 10% on activated carbon; hydrogenchloride; hydrogen / methanol; water / 50 °C / 38002.6 Torr / Autoclave

With hydrogenchloride; palladium 10% on activated carbon; hydrogen; lithium diisopropyl amide; In tetrahydrofuran; methanol; water;

DOI:10.1002/ejoc.201900450

upstream raw materials:

2-bromo-pyridine

2-(2-bromopyridin-3-yl)propan-2-ol

5-methyl-4-hexenal

2-(2-chloropyridin-3-yl)propan-2-ol