3,6-dimethyl-1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocin-8-ol

Base Information

• Chemical Name: 3,6-dimethyl-1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocin-8-ol
• CAS No.: 20649-16-5
• Molecular Formula: C14H19NO
• Molecular Weight: 217.3068
• Mol file: 20649-16-5.mol

Synonyms:

Chemical Property of 3,6-dimethyl-1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocin-8-ol

Chemical Property:

• Vapor Pressure: 4.65E-05mmHg at 25°C
• Boiling Point: 339.5°C at 760 mmHg
• Flash Point: 162.5°C
• Density: 1.115g/cm³

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3,6-dimethyl-1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocin-8-ol

There total 4 articles about 3,6-dimethyl-1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocin-8-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ (R)-3,6-Dimethyl-1,2,3,4,5,6-hexahydro-2,6-methano-benzo[d]azocin-8-ol (20649-16-5,20649-36-9,21373-18-2,21373-19-3)

Guidance literature:

Olefin 5a, PPA, Δ;

DOI:10.1021/jo01264a087

Reference yield:

→ 2'-Hydroxy-2,5-dimethyl-6,7-benzomorphan (20649-16-5)

Guidance literature:

With methanol; Pd-BaSO₄; Hydrogenation_.Behandeln des Reaktionsprodukts mit wss. Natriumnitrit-Loesung und Erwaermen des Gemisches mit wss. Schwefelsaeure_.;

DOI:10.1021/jo01362a018

Reference yield:

4-methoxybenzylmagnesium chloride (38769-92-5) + N-methyl-4-methylpyridinium iodide (2301-80-6) → 2'-Hydroxy-2,5-dimethyl-6,7-benzomorphan (20649-16-5) + 4-(1,4-Dimethyl-[2]piperidylmethyl)-phenol (101775-32-0)

Guidance literature:

With diethyl ether; Hydrieren des Reaktionsprodukts in wss. Salzsaeure an Palladium/Bariumsulfat und folgenden Erhitzen mit wss. Bromwasserstoffsaeure auf 135-140grad.;

DOI:10.1021/jo01362a018

upstream raw materials:

4-methoxybenzylmagnesium chloride

N-methyl-4-methylpyridinium iodide