4-Methoxybenzylmagnesium chloride

Base Information

• Chemical Name: 4-Methoxybenzylmagnesium chloride
• CAS No.: 38769-92-5
• Molecular Formula: C8H9ClMgO
• Molecular Weight: 180.917
• Hs Code.: 29319090
• European Community (EC) Number: 695-992-0
• Mol file: 38769-92-5.mol

Synonyms:4-methoxybenzylmagnesium chloride;38769-92-5;Magnesium, chloro[(4-methoxyphenyl)methyl]-;MFCD01311491;SCHEMBL467216;p-methoxybenzylmagnesium chloride;p-methoxybenzyl magnesium chloride;4-methoxy benzylmagnesium chloride;XHDYUCUVUZSISM-UHFFFAOYSA-M;(4-methoxybenzyl)magnesium chloride;AKOS015889288;4-Methoxybenzylmagnesium chloride, 0.25M in 2-MeTHF;4-Methoxybenzylmagnesium chloride, 0.25 M in 2-MeTHF;4-Methoxybenzylmagnesium chloride 0.25 M in Tetrahydrofuran

Chemical Property of 4-Methoxybenzylmagnesium chloride

Chemical Property:

• Boiling Point: 65 °C
• Flash Point: 1 °F
• PSA: 9.23000
• Density: 0.914 g/mL at 25 °C
• LogP: 2.70040
• Storage Temp.: 2-8°C
• Sensitive.: Air & Moisture Sensitive
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 180.0192343
• Heavy Atom Count: 11
• Complexity: 82.2

Purity/Quality:

98%,99%, ^*data from raw suppliers

4-Methoxybenzylmagnesium chloride solution 0.25 M in THF ^*data from reagent suppliers

Safty Information:

• Pictogram(s): F,C
• Hazard Codes: F,C,Xn
• Statements: 11-14/15-19-34-40-36/37-14
• Safety Statements: 16-26-33-36/37/39-43-45-36/37-60-8

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)[CH2-].[Mg+2].[Cl-]

Technology Process of 4-Methoxybenzylmagnesium chloride

There total 1 articles about 4-Methoxybenzylmagnesium chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

p-methoxybenzyl chloride (824-94-2) → 4-methoxybenzylmagnesium chloride (38769-92-5)

Guidance literature:

With iodine; magnesium; In tetrahydrofuran; for 1h;

DOI:10.1002/chem.200304718

Reference yield: 96.0%

(S)-2-ethenyl-2,6-dimethylhept-5-enal (1020108-54-6) + 4-methoxybenzylmagnesium chloride (38769-92-5) → (3S)-3-ethenyl-1-(4-methoxyphenyl)-3,7-dimethyloct-6-en-2-ol (1020108-55-7)

Guidance literature:

In tetrahydrofuran; at 0 - 20 ℃; for 2.25h;

DOI:10.1002/hlca.200890041

Reference yield: 92.0%

3,7-dimethyl-2E,6-octadien-1-yl acetate (105-87-3,8022-83-1) + 4-methoxybenzylmagnesium chloride (38769-92-5) → trans-1-(4,8-dimethylnona-3,7-dien-1-yl)-4-methoxybenzene (38011-83-5)

Guidance literature:

With dilithium tetrachlorocuprate; In tetrahydrofuran; at 0 ℃; for 2h;

DOI:10.1016/j.ejmech.2018.04.032

upstream raw materials:

p-methoxybenzyl chloride

Downstream raw materials:

(4-methoxy-benzyl)-trimethyl-silane

8-(4-methoxy-benzyl)-5,6,7,8-tetrahydro-isoquinolin-8-ol

9-(4-methoxybenzylidene)-9H-xanthene

9-(4-methoxy-benzylidene)-thioxanthene

Refernces