5-FLUORO-1-METHYL-1H-INDOLE-2-CARBALDEHYDE

Base Information

• Chemical Name: 5-FLUORO-1-METHYL-1H-INDOLE-2-CARBALDEHYDE
• CAS No.: 883531-48-4
• Molecular Formula: C10H8FNO
• Molecular Weight: 177.18
• Mol file: 883531-48-4.mol

Synonyms:5-FLUORO-1-METHYL-1H-INDOLE-2-CARBALDEHYDE;5-fluoro-1-methyl-1H-indole-2-carbaldehyde(SALTDATA: FREE)

Chemical Property of 5-FLUORO-1-METHYL-1H-INDOLE-2-CARBALDEHYDE

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 322.322°C at 760 mmHg
• Flash Point: 148.736°C
• PSA: 22.00000
• Density: 1.209g/cm³
• LogP: 2.12990

Purity/Quality:

97% ^*data from raw suppliers

5-fluoro-1-methyl-1H-indole-2-carbaldehyde ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-FLUORO-1-METHYL-1H-INDOLE-2-CARBALDEHYDE

There total 1 articles about 5-FLUORO-1-METHYL-1H-INDOLE-2-CARBALDEHYDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

(5-fluoro-1-methyl-1H-indol-2-yl)methanol (906543-03-1) → 5-fluoro-1-methyl-1H-indole-2-carbaldehyde (883531-48-4)

Guidance literature:

With manganese(IV) oxide; In dichloromethane; at 20 ℃; for 17h;

DOI:10.1002/chem.201502287

Reference yield: 90.0%

2,3-dihydro-2H-furan (1191-99-7,75454-45-4) + 5-fluoro-1-methyl-1H-indole-2-carbaldehyde (883531-48-4) + 4-chloro-aniline (106-47-8) → (3aR*,4R*,9cR*)-N-(4-chlorophenyl)-8-fluoro-5-methyl-2,3,3a,4,5,9c-hexahydrofuro[2',3':3,4]cyclopenta[1,2-b]indol-4-amine

Guidance literature:

5-fluoro-1-methyl-1H-indole-2-carbaldehyde; 4-chloro-aniline; With diphenyl hydrogen phosphate; In dichloromethane; at 0 - 20 ℃; for 1h; Inert atmosphere; Molecular sieve;

2,3-dihydro-2H-furan; In dichloromethane; at 20 ℃; for 5h; stereoselective reaction; Inert atmosphere; Molecular sieve;

DOI:10.1002/chem.201503044

Reference yield: 87.0%

2,3-dihydro-2H-furan (1191-99-7,75454-45-4) + 5-fluoro-1-methyl-1H-indole-2-carbaldehyde (883531-48-4) + aniline (62-53-3) → (3aR*,4R*,9cR*)-8-fluoro-5-methyl-N-phenyl-2,3,3a,4,5,9c-hexahydrofuro[2',3':3,4]cyclopenta[1,2-b]indol-4-amine

Guidance literature:

5-fluoro-1-methyl-1H-indole-2-carbaldehyde; aniline; With diphenyl hydrogen phosphate; In dichloromethane; at 0 - 20 ℃; for 1h; Inert atmosphere; Molecular sieve;

2,3-dihydro-2H-furan; In dichloromethane; at 20 ℃; for 5h; stereoselective reaction; Inert atmosphere; Molecular sieve;

DOI:10.1002/chem.201503044

upstream raw materials:

(5-fluoro-1-methyl-1H-indol-2-yl)methanol

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