Spiro[2H-1-benzopyran-2,4'-piperidine]-1'-carboxylic acid, 1,1-diMethylethyl ester

Base Information

• Chemical Name: Spiro[2H-1-benzopyran-2,4'-piperidine]-1'-carboxylic acid, 1,1-diMethylethyl ester
• CAS No.: 1207163-67-4
• Molecular Formula: C₁₈H₂₃NO₃
• Molecular Weight: 301.386
• Hs Code.: 2934999090
• Mol file: 1207163-67-4.mol

Synonyms:Spiro[2H-1-benzopyran-2,4'-piperidine]-1'-carboxylic acid, 1,1-diMethylethyl ester

Chemical Property of Spiro[2H-1-benzopyran-2,4'-piperidine]-1'-carboxylic acid, 1,1-diMethylethyl ester

Chemical Property:

• PSA: 38.77000
• LogP: 3.79980
• Storage Temp.: 2-8°C

Purity/Quality:

≥99% ^*data from raw suppliers

tert-Butylspiro[chromene-2,4'-piperidine]-1'-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Spiro[2H-1-benzopyran-2,4'-piperidine]-1'-carboxylic acid, 1,1-diMethylethyl ester

There total 6 articles about Spiro[2H-1-benzopyran-2,4'-piperidine]-1'-carboxylic acid, 1,1-diMethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

di-tert-butyl dicarbonate (24424-99-5) + spiro[chromene-2,4'-piperidine] → tert-butyl 1'H-spiro[chromene-2,4'-piperidine]-1'-carboxylate (1207163-67-4)

Guidance literature:

With sodium hydroxide; In 1,4-dioxane; water; at 0 - 20 ℃; for 3h;

DOI:10.1016/j.bmcl.2015.05.087

Reference yield: 78.0%

tert-butyl 4-hydroxy-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidine]-1'-carboxylate (1024604-94-1) → tert-butyl 1'H-spiro[chromene-2,4'-piperidine]-1'-carboxylate (1207163-67-4)

Guidance literature:

tert-butyl 4-hydroxy-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidine]-1'-carboxylate; In 1,4-dioxane; at 60 - 90 ℃; for 2h;

With di-tert-butyl dicarbonate; triethylamine; In dichloromethane; at 20 ℃; for 0.166667h;

Reference yield:

C19H27NO6S → tert-butyl 1'H-spiro[chromene-2,4'-piperidine]-1'-carboxylate (1207163-67-4)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In 1-methyl-pyrrolidin-2-one; at 100 ℃;

DOI:10.1016/j.bmcl.2009.11.043

upstream raw materials:

o-hydroxyacetophenone

tert-butyl 4-oxo-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidine]-1'-carboxylate

N-tert-butyloxycarbonylpiperidin-4-one

tert-butyl 4-hydroxy-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidine]-1'-carboxylate

Downstream raw materials:

1'-(tert-butoxycarbonyl)spiro[chromene-2,4'-piperidine]-4-carboxylic acid

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