Spiro[2H-1-benzopyran-2,4'-piperidine]-1'-carboxylic acid, 3,4-dihydro-4-hydroxy-, 1,1-diMethylethyl ester

Base Information

• Chemical Name: Spiro[2H-1-benzopyran-2,4'-piperidine]-1'-carboxylic acid, 3,4-dihydro-4-hydroxy-, 1,1-diMethylethyl ester
• CAS No.: 1024604-94-1
• Molecular Formula: C₁₈H₂₅NO₄
• Molecular Weight: 319.401
• Hs Code.: 2934999090
• Mol file: 1024604-94-1.mol

Synonyms:Spiro[2H-1-benzopyran-2,4'-piperidine]-1'-carboxylic acid, 3,4-dihydro-4-hydroxy-, 1,1-diMethylethyl ester

Chemical Property of Spiro[2H-1-benzopyran-2,4'-piperidine]-1'-carboxylic acid, 3,4-dihydro-4-hydroxy-, 1,1-diMethylethyl ester

Chemical Property:

• PSA: 59.00000
• LogP: 3.21010

Purity/Quality:

≥99% ^*data from raw suppliers

tert-butyl4-hydroxyspiro[chromane-2,4''-piperidine]-1''-carboxylate 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Spiro[2H-1-benzopyran-2,4'-piperidine]-1'-carboxylic acid, 3,4-dihydro-4-hydroxy-, 1,1-diMethylethyl ester

There total 3 articles about Spiro[2H-1-benzopyran-2,4'-piperidine]-1'-carboxylic acid, 3,4-dihydro-4-hydroxy-, 1,1-diMethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

tert-butyl 4-oxo-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidine]-1'-carboxylate (849928-22-9) → tert-butyl 4-hydroxy-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidine]-1'-carboxylate (1024604-94-1)

Guidance literature:

With sodium tetrahydroborate; In methanol; at 0 - 20 ℃;

DOI:10.1016/j.ejmech.2010.07.044

Reference yield:

o-hydroxyacetophenone (118-93-4,104809-67-8) → tert-butyl 4-hydroxy-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidine]-1'-carboxylate (1024604-94-1)

Guidance literature:

Multi-step reaction with 2 steps

1: pyrrolidine / methanol / 2.5 h / 80 °C

2: ethanol; sodium tetrahydroborate / 2.75 h / 75 °C

With pyrrolidine; sodium tetrahydroborate; ethanol; In methanol;

Reference yield:

N-tert-butyloxycarbonylpiperidin-4-one (79099-07-3) → tert-butyl 4-hydroxy-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidine]-1'-carboxylate (1024604-94-1)

Guidance literature:

Multi-step reaction with 2 steps

1: pyrrolidine / methanol / 2.5 h / 80 °C

2: ethanol; sodium tetrahydroborate / 2.75 h / 75 °C

With pyrrolidine; sodium tetrahydroborate; ethanol; In methanol;

upstream raw materials:

tert-butyl 4-oxo-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidine]-1'-carboxylate

o-hydroxyacetophenone

N-tert-butyloxycarbonylpiperidin-4-one

Downstream raw materials:

tert-butyl 1'H-spiro[chromene-2,4'-piperidine]-1'-carboxylate

1'-(tert-butoxycarbonyl)spiro[chromene-2,4'-piperidine]-4-carboxylic acid

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