(R)-ALPHA-PHENYL-1-PYRROLIDINEETHANAMINE

Base Information

• Chemical Name: (R)-ALPHA-PHENYL-1-PYRROLIDINEETHANAMINE
• CAS No.: 180305-85-5
• Molecular Formula: C12H18N2
• Molecular Weight: 190.288
• Hs Code.: 2933998090
• Mol file: 180305-85-5.mol

Synonyms:(R)-ALPHA-PHENYL-1-PYRROLIDINEETHANAMINE;(R)-a-Phenyl-1-pyrrolidineethanaMine 2HCl

Chemical Property of (R)-ALPHA-PHENYL-1-PYRROLIDINEETHANAMINE

Chemical Property:

• PSA: 29.26000
• LogP: 2.42040

Purity/Quality:

99% ^*data from raw suppliers

(1R)-1-Phenyl-2-(pyrrolidin-1-yl)ethan-1-aminedihydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (R)-ALPHA-PHENYL-1-PYRROLIDINEETHANAMINE

There total 8 articles about (R)-ALPHA-PHENYL-1-PYRROLIDINEETHANAMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

(R)‐2‐amino‐2‐phenyl‐1‐(pyrrolidin‐1‐yl)ethan‐1‐one (190442-37-6) → (R)-1-phenyl-2-(pyrrolidin-1-yl)ethanamine (180305-85-5)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; for 6h; Heating;

DOI:10.1021/jo960244v

Reference yield:

pyrrolidine (123-75-1) + (R)-Styrene oxide (20780-53-4) → (R)-1-phenyl-2-(pyrrolidin-1-yl)ethanamine (180305-85-5)

Guidance literature:

With ammonium hydroxide; methanesulfonyl chloride; triethylamine; Yield given. Multistep reaction; 1.) EtOH, reflux; 2.) Et₂O, 0 deg C, 30 min; 3.) Et₂O, r.t., 16 h;

DOI:10.1016/0040-4039(96)01140-9

Reference yield:

Z-D-phenylglycine (17609-52-8) → (R)-1-phenyl-2-(pyrrolidin-1-yl)ethanamine (180305-85-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) CuCl₂, 1-hydroxybenzotriazole, DCC / 1) DMF, 0 deg C, 20 min; 2) DMF, 0 deg C --> rt, 20 h

2: 95 percent / H₂ / Pd/C / methanol / 2 h

3: 77 percent / LAH / tetrahydrofuran / 6 h / Heating

With lithium aluminium tetrahydride; hydrogen; benzotriazol-1-ol; dicyclohexyl-carbodiimide; copper dichloride; palladium on activated charcoal; In tetrahydrofuran; methanol;

DOI:10.1021/jo960244v

upstream raw materials:

(R)‐2‐amino‐2‐phenyl‐1‐(pyrrolidin‐1‐yl)ethan‐1‐one

pyrrolidine

(R)-Styrene oxide

(2S)-2-phenylglycinol

Downstream raw materials:

N-(tert-butoxycarbonyl)-3-(S)-(1-(R)-phenyl-2-N'-pyrrolidinylethyl)aminopyrrolidine