2-(4-Chlorophenoxy)-5-nitropyridine

Base Information

• Chemical Name: 2-(4-Chlorophenoxy)-5-nitropyridine
• CAS No.: 28232-30-6
• Molecular Formula: C11H7 Cl N2 O3
• Molecular Weight: 250.641
• Hs Code.: 2933399090
• NSC Number: 125714
• DSSTox Substance ID: DTXSID00298748
• Wikidata: Q82040768
• Mol file: 28232-30-6.mol

Synonyms:2-(4-Chlorophenoxy)-5-nitropyridine;28232-30-6;NSC125714;Maybridge1_001077;VANADIUM(III)CHLORIDE;4-Chlorophenoxy-5-nitropyridine;SCHEMBL11274403;HMS544I21;DTXSID00298748;2-[p-Chlorophenoxy]-5-nitropyridine;CCG-52336;MFCD00116453;AKOS001127540;NSC-125714;2-(4-Chlorophenoxy)-5-nitropyridine #;CS-10610;CS-0358702;FT-0714688;2-(4-chlorophenoxy)-5-nitropyridine, AldrichCPR;J-505942;SR-01000641579-1

Chemical Property of 2-(4-Chlorophenoxy)-5-nitropyridine

Chemical Property:

• Vapor Pressure: 3.5E-05mmHg at 25°C
• Melting Point: 93 °C
• Boiling Point: 364.6°Cat760mmHg
• Flash Point: 174.3°C
• PSA: 67.94000
• Density: 1.415g/cm³
• LogP: 3.95870
• XLogP3: 3.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 250.0145198
• Heavy Atom Count: 17
• Complexity: 264

Purity/Quality:

98%min ^*data from raw suppliers

2-(4-Chlorophenoxy)-5-nitropyridine 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T
• Hazard Codes: T
• Statements: 25-43
• Safety Statements: 36/37-45

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=CC=C1OC2=NC=C(C=C2)[N+](=O)[O-])Cl

Technology Process of 2-(4-Chlorophenoxy)-5-nitropyridine

There total 4 articles about 2-(4-Chlorophenoxy)-5-nitropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2-chloro-5-nitropyridine (4548-45-2) + sodium 4-chlorophenolate (1193-00-6) → 2-(4'-chlorophenoxy)-5-nitropyridine (28232-30-6)

Guidance literature:

In methanol; Heating;

DOI:10.1002/(SICI)1099-1395(199904)12:4<347::AID-POC134>3.0.CO;2-G

Reference yield: 94.0%

2-chloro-5-nitropyridine (4548-45-2) + 4-chloro-phenol (106-48-9,82344-39-6) → 2-(4'-chlorophenoxy)-5-nitropyridine (28232-30-6)

Guidance literature:

4-chloro-phenol; With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 3h;

2-chloro-5-nitropyridine; In N,N-dimethyl-formamide; at 80 ℃;

Reference yield:

2-chloro-5-nitropyridine (4548-45-2) + potassium 4-chlorophenoxide (1121-74-0) → 2-(4'-chlorophenoxy)-5-nitropyridine (28232-30-6)

Guidance literature:

With ethanol;

upstream raw materials:

2-chloro-5-nitropyridine

potassium 4-chlorophenoxide

4-chloro-phenol

sodium 4-chlorophenolate

Downstream raw materials:

6-(4-chlorophenoxy)-3-aminopyridine