2-Chloro-3-chloromethyl-6-methylquinoline

Base Information

Chemical Name:2-Chloro-3-chloromethyl-6-methylquinoline
CAS No.:948291-18-7
Molecular Formula:C11H9Cl2N
Molecular Weight:226.105
Hs Code.:
DSSTox Substance ID:DTXSID30588982
Wikidata:Q82482036
Mol file:948291-18-7.mol

Synonyms:2-Chloro-3-chloromethyl-6-methylquinoline;948291-18-7;2-chloro-3-(chloromethyl)-6-methylquinoline;SCHEMBL14617051;DTXSID30588982;MFCD07780130;AB42545;DA-26671

Suppliers and Price of 2-Chloro-3-chloromethyl-6-methylquinoline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
2-CHLORO-3-CHLOROMETHYL-6-METHYLQUINOLINE 95.00%
5MG
$ 504.26

Total 6 raw suppliers

Chemical Property of 2-Chloro-3-chloromethyl-6-methylquinoline

Chemical Property:

Vapor Pressure:0.000101mmHg at 25°C
Boiling Point:348.5°C at 760 mmHg
Flash Point:195.5°C
PSA：12.89000
Density:1.309g/cm³
LogP:3.93540
XLogP3:3.9
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:1
Exact Mass:225.0112047
Heavy Atom Count:14
Complexity:198

Purity/Quality:

98%min ^*data from raw suppliers

2-CHLORO-3-CHLOROMETHYL-6-METHYLQUINOLINE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=CC2=CC(=C(N=C2C=C1)Cl)CCl

Technology Process of 2-Chloro-3-chloromethyl-6-methylquinoline

There total 4 articles about 2-Chloro-3-chloromethyl-6-methylquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 123637-97-8
3-(hydroxymethyl)-2-chloro-6-methylquinoline

: 948291-18-7
2-chloro-3-(chloromethyl)-6-methylquinoline

Guidance literature:: With thionyl chloride; In dichloromethane; N,N-dimethyl-formamide; Reflux;
DOI:10.1039/c5nj02566d

Reference yield:

: 73568-27-1
2-chloro-6-methylquinoline-3-carbaldehyde

: 948291-18-7
2-chloro-3-(chloromethyl)-6-methylquinoline

Guidance literature:: Multi-step reaction with 2 steps

1: sodium tetrahydroborate / methanol / 0.5 h / 20 °C

2: thionyl chloride / benzene / 4 h / Reflux

With sodium tetrahydroborate; thionyl chloride; In methanol; benzene;
DOI:10.1002/ardp.201000352

Reference yield:

: 103-89-9
4-Methylacetanilide

: 948291-18-7
2-chloro-3-(chloromethyl)-6-methylquinoline

Guidance literature:: Multi-step reaction with 3 steps

1.1: trichlorophosphate / 1 h / 0 - 5 °C

1.2: 0 - 80 °C / Inert atmosphere

2.1: sodium tetrahydroborate / methanol / 0.5 h / 20 °C

3.1: thionyl chloride / dichloromethane / 6 h / 50 °C

With sodium tetrahydroborate; thionyl chloride; trichlorophosphate; In methanol; dichloromethane; 1.1: |Vilsmeier-Haack Formylation / 1.2: |Vilsmeier-Haack Formylation;
DOI:10.1016/j.bmcl.2021.127855