PL-100

Base Information

Chemical Name:PL-100
CAS No.:612547-11-2
Molecular Formula:C33H44N4O6S
Molecular Weight:624.802
Hs Code.:
Mol file:612547-11-2.mol

Synonyms:PL-100;N-[(1S)-1-[[[(5S)-5-[[(4-Aminophenyl)sulfonyl](2-methylpropyl)amino]-6-hydroxyhexyl]amino]carbonyl]-2,2-diphenylethyl]carbamic acid methyl ester

Suppliers and Price of PL-100

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 14 raw suppliers

Chemical Property of PL-100

Chemical Property:

PSA：166.42000
Density:1.217
LogP:6.82630

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of PL-100

There total 9 articles about PL-100 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 612547-11-2
(1S,5S)-(1-{5-[(4-amino-benzenesulfonyl)-isobutyl-amino]-6-hydroxy-hexylcarbamoyl}-2,2-diphenyl-ethyl)-carbamic acid methyl ester

Guidance literature:

Reference yield:

: 21568-87-6
2-aminocaprolactam

: 612547-11-2
(1S,5S)-(1-{5-[(4-amino-benzenesulfonyl)-isobutyl-amino]-6-hydroxy-hexylcarbamoyl}-2,2-diphenyl-ethyl)-carbamic acid methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 89 percent / STAB / CH₂Cl₂

2: 88 percent / TEA / ethyl acetate

3: DMAP / acetonitrile

4: NaBH₄ / ethanol / 6 h

5: 95 percent / HCl / ethanol / 20 °C

6: EDAC; HOBt / dimethylformamide

With hydrogenchloride; dmap; sodium tetrahydroborate; TEA; sodium tris(acetoxy)borohydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.bmcl.2006.04.011

Reference yield:

: 900187-22-6
(1-S)-{4-[(5-tert-butoxycarbonylamino-1-hydroxymethyl-pentyl)-isobutyl-sulfamoyl]-phenyl}-carbamic acid tert-butyl ester

: 612547-11-2
(1S,5S)-(1-{5-[(4-amino-benzenesulfonyl)-isobutyl-amino]-6-hydroxy-hexylcarbamoyl}-2,2-diphenyl-ethyl)-carbamic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 95 percent / HCl / ethanol / 20 °C

2: EDAC; HOBt / dimethylformamide

With hydrogenchloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In ethanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2006.04.011