Nα-Cbz-L-Methioninamide

Base Information

• Chemical Name: Nα-Cbz-L-Methioninamide
• CAS No.: 77178-77-9
• Molecular Formula: C₁₃H₁₈N₂O₃S
• Molecular Weight: 282.364
• Mol file: 77178-77-9.mol

Synonyms:Nα-Cbz-L-Methioninamide

Chemical Property of Nα-Cbz-L-Methioninamide

Chemical Property:

• Boiling Point: 523.6±50.0 °C(Predicted)
• PKA: 10.94±0.46(Predicted)
• Density: 1 +-.0.06 g/cm3(Predicted)

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Nα-Cbz-L-Methioninamide

There total 3 articles about Nα-Cbz-L-Methioninamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

Cbz-Met-OH (1152-62-1) → Z-Met-NH2 (15998-52-4,77178-77-9)

Guidance literature:

Cbz-Met-OH; With chloroformic acid ethyl ester; triethylamine; In tetrahydrofuran; at 0 ℃; for 0.5h;

With ammonium chloride; In tetrahydrofuran; water; at 0 ℃; for 0.5h;

DOI:10.1016/j.tetasy.2017.10.015

Reference yield:

C16H21NO6S → Z-Met-NH2 (15998-52-4,77178-77-9)

Guidance literature:

With ammonium chloride; In tetrahydrofuran; water; at 0 ℃; for 0.5h;

DOI:10.1246/cl.130096

Reference yield:

methyl (S)-2-(benzyloxycarbonylamino)-4-methylmercaptobutanoate (56762-93-7) → Z-Met-NH2 (15998-52-4,77178-77-9)

Guidance literature:

With ammonia;

upstream raw materials:

methyl (S)-2-(benzyloxycarbonylamino)-4-methylmercaptobutanoate

Cbz-Met-OH

Downstream raw materials:

((S)-1-Cyano-3-methylsulfanyl-propyl)-carbamic acid benzyl ester