2-Hydroxy-7-iodonaphthalene

Base Information

• Chemical Name: 2-Hydroxy-7-iodonaphthalene
• CAS No.: 128542-51-8
• Molecular Formula: C10H7IO
• Molecular Weight: 270.06645
• Mol file: 128542-51-8.mol

Synonyms:2-Hydroxy-7-iodonaphthalene

Chemical Property of 2-Hydroxy-7-iodonaphthalene

Chemical Property:

• PSA: 20.23000
• LogP: 3.15000

Purity/Quality:

97% ^*data from raw suppliers

2-Iodo-7-naphthol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Hydroxy-7-iodonaphthalene

There total 4 articles about 2-Hydroxy-7-iodonaphthalene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-7-iodonaphthalene (1314130-90-9) → 7-iodonaphthalen-2-ol (128542-51-8)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 2h;

DOI:10.1039/c9cc07834g

Reference yield:

2-bromo-7-[[(1,1-dimethylethyl)dimethylsilyl]oxy]naphthalene (1314130-89-6) → 7-iodonaphthalen-2-ol (128542-51-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: n-butyllithium / tetrahydrofuran; hexanes / 0.5 h / -78 - -65 °C / Inert atmosphere

1.2: 20 °C

2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 20 °C

With n-butyllithium; tetrabutyl ammonium fluoride; In tetrahydrofuran; hexanes;

Reference yield:

7-bromonaphthalen-2-ol (116230-30-9) → 7-iodonaphthalen-2-ol (128542-51-8)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 1H-imidazole / dichloromethane / 0 - 20 °C

2.1: n-butyllithium / tetrahydrofuran; hexanes / 0.5 h / -78 - -65 °C / Inert atmosphere

2.2: 20 °C

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 20 °C

With 1H-imidazole; n-butyllithium; tetrabutyl ammonium fluoride; In tetrahydrofuran; hexanes; dichloromethane;

upstream raw materials:

7-bromonaphthalen-2-ol

2-bromo-7-[[(1,1-dimethylethyl)dimethylsilyl]oxy]naphthalene

2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-7-iodonaphthalene

C₁₀H₉IO₂

Refernces

• 1、 -. "FUNGICIDAL 2-(BICYCLIC ARYLOXY)CARBOXAMIDES". . . Retrieved 2012/07/13.
• 2、 Kudavalli, Jaya Satyanarayana,Boyd, Derek R.,Sharma, Narain D.,More O'Ferrall, Rory A.. "Acid-catalyzed dehydration of naphthalene-cis-1,2-dihydrodiols: Origin of impaired resonance effect of 3-substituents". supporting information; experimental part. p. 9338 - 9343. Retrieved 2012/01/03.