116230-30-9Relevant academic research and scientific papers
Synthesis and Photochromism of Novel Pyridyl-Substituted Naphthopyrans
De Azevedo, Orlando D. C. C.,Elliott, Paul I. P.,Gabbutt, Christopher D.,Heron, B. Mark,Lord, Kyle J.,Pullen, Christopher
, p. 10772 - 10796 (2020/09/23)
Multitarget synthetic strategies to access novel photochromic 3H-naphtho[2,1-b]pyrans decorated with pyridyl units are described. The new pyridyl-substituted 3H-naphtho[2,1-b]pyrans display good photochromic properties with reversible generation of photomerocyanines, which exhibit mainly orange/red hues. Photochromic parameters including photocolorability and persistence of color vary tremendously on structural modification of the naphthopyran core.
Practical and Scalable Kinetic Resolution of BINOLs Mediated by a Chiral Counterion
Jones, Benjamin A.,Balan, Tudor,Jolliffe, John D.,Campbell, Craig D.,Smith, Martin D.
supporting information, p. 4596 - 4600 (2019/03/13)
BINOLs are valuable and widely used building blocks, chiral ligands, and catalysts that are effective across a remarkable range of different chemical transformations. Here we demonstrate that an ammonium salt catalyzed kinetic resolution of racemic BINOLs with benzyl tosylate proceeds with s up to 46. This is a scalable and practical process that can be applied across >30 different C2- and non-C2-symmetric BINOLs. Implementation of this method enables the enantioselective synthesis of a wide range of BINOL derivatives with over 99:1 e.r.
GRAPHENE NANORIBBONS WITH CONTROLLED ZIG-ZAG EDGE AND COVE EDGE CONFIGURATION
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Page/Page column 32; 33, (2015/09/22)
Provided are graphene nanoribbons with controlled zig-zag edge and cove edge configuration and methods for preparing such graphene nanoribbons. The nanoribbons are selected from the following formulae.
Synthesis and photochromism of a spirooxazine derivative featuring a carbazole moiety: Fast thermal bleaching and excellent fatigue resistance
Zou, Qi,Li, Xin,Zhou, Ji,Bai, Kangkang,?gren, Hans
, p. 174 - 181 (2014/05/06)
A novel photochromic spirooxazine derivative bearing a carbazole moiety (SOC) was synthesized and studied in solution under flash photolysis conditions. It is found to exhibit excellent characteristics like high photochromic response, large steady-state optical density, fast thermal bleaching rate and good fatigue-resistance. The effect of different solvents on the photochromic properties of the compound was evaluated, revealing that the photochromic properties can be modulated by different solvents based on the corresponding polarity. The mechanism and kinetics of the thermal fading process of compound SOC were additionally investigated by theoretical simulations, where the isomerization pathway from the trans-trans-cis conformation was found to be several times faster than that from the cis-trans-cis conformation. This type of fast-bleaching and fatigue-resistent photochromic compounds is expected to pave an exciting avenue in future development of high-performance photochromic materials.
Potent BRAF kinase inhibitors based on 2,4,5-trisubstituted imidazole with naphthyl and benzothiophene 4-substituents
Niculescu-Duvaz, Dan,Niculescu-Duvaz, Ion,Suijkerbuijk, Bart M.J.M.,Ménard, Delphine,Zambon, Alfonso,Davies, Lawrence,Pons, Jean-Francois,Whittaker, Steven,Marais, Richard,Springer, Caroline J.
, p. 1284 - 1304 (2013/03/14)
The RAS-RAF-MEK-ERK pathway is hyperactivated in 30% of human cancers. BRAF is a serine-threonine kinase, belonging to this pathway that is mutated with high frequency in human melanoma and other cancers thus BRAF is an important therapeutic target in melanoma. We have designed inhibitors of BRAF based on 2,4,5-trisubstituted imidazoles with naphthyl and benzothiophene-4-substituents. Two compounds were discovered to be potent BRAF inhibitors: 1-(6-{2-[4-(2-dimethylamino-ethoxy)phenyl]-5-(pyridin-4-yl)-1H-imidazol-4-yl} benzo[b]thiophen-3-yl)-2,2,2-trifluoroethanol (1i) with BRAF IC50 = 190 nM and with cellular GI50 = 2100 nM, and 6-{2-[4-(2- dimethylamino-ethoxy)-phenyl]-5-pyridin-4-yl-3H-imidazol-4-yl}-naphthalen-1-ol (1q) with IC50 = 9 nM and GI50 = 220 nM.
Intrinsically thermochromic fluorans
Azizian, Farid,Field, Amanda J.,Heron, B. Mark,Kilner, Colin
supporting information; experimental part, p. 750 - 752 (2012/02/02)
A Suzuki coupling strategy has been employed to access a series of novel fluorans substituted with a phenolic moiety. These fluorans display good thermochromism in methyl stearate and obviate the need for traditional complex formulations containing acidic colour developers.
Light-controlled supramolecular helicity of a liquid crystalline phase using a helical polymer functionalized with a single chiroptical molecular switch
Pijper, Dirk,Jongejan, Mahthild G. M.,Meetsma, Auke,Feringa, Ben L.
, p. 4541 - 4552 (2008/12/20)
Control over the preferred helical sense of a poly(n-hexyl isocyanate) (PHIC) by using a single light-driven molecular motor, covalently attached at the polymer's terminus, has been accomplished in solution via a combination of photochemical and thermal isomerizations. Here, we report that after redesigning the photochromic unit to a chiroptical molecular switch, of which the two states are thermally stable but photochemically bistable, the chiral induction to the polymer's backbone is significantly improved and the handedness of the helical polymer is addressable by irradiation with two different wavelengths of light. Moreover, we show that the chiral information is transmitted, via the macromolecular level of the poly isocyanate, to the supramolecular level of a lyotropic cholesteric liquid crystalline phase consisting of these stiff, rodlike polymers. This allows the magnitude and sign of the supramolecular helical pitch of the liquid crystal film to be fully controlled by light.
Indole derivatives for the treatment of depression and anxiety
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Page/Page column 14, (2010/02/05)
The present invention provides compounds of formula (I): which are useful for treating depression, anxiety, and alleviating the symptoms caused by withdrawal or partial withdrawal from the use of tobacco or of nicotine.
Benzofuran derivatives
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Page 13, (2010/02/06)
The present invention provides compounds of formula (I) which are useful for treating depression, anxiety, and alleviating the symptoms caused by withdrawal or partial withdrawal from the use of tobacco or of nicotine.
Piperidines derivatives and their use as serotonin receptor antagonists
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Page 13, (2010/02/05)
The present invention provides compounds of formula (I): which are useful for treating depression, anxiety, and alleviating the symptoms caused by withdrawal or partial withdrawal from the use of tobacco or of nicotine.
