(1s,4s)-4-(1,3-dioxoisoindolin-2-yl)cyclohexyl 4-nitrobenzoate

Base Information

Chemical Name:(1s,4s)-4-(1,3-dioxoisoindolin-2-yl)cyclohexyl 4-nitrobenzoate
CAS No.:478832-23-4
Molecular Formula:C21H18N2O6
Molecular Weight:394.384
Hs Code.:
Mol file:478832-23-4.mol

Synonyms:(1s,4s)-4-(1,3-dioxoisoindolin-2-yl)cyclohexyl 4-nitrobenzoate

Suppliers and Price of (1s,4s)-4-(1,3-dioxoisoindolin-2-yl)cyclohexyl 4-nitrobenzoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 3 raw suppliers

Chemical Property of (1s,4s)-4-(1,3-dioxoisoindolin-2-yl)cyclohexyl 4-nitrobenzoate

Chemical Property:

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

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Technology Process of (1s,4s)-4-(1,3-dioxoisoindolin-2-yl)cyclohexyl 4-nitrobenzoate

There total 4 articles about (1s,4s)-4-(1,3-dioxoisoindolin-2-yl)cyclohexyl 4-nitrobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 99337-98-1
2-((1R,4R)-4-hydroxycyclohexyl) isoindoline-1,3-dione

: 62-23-7
4-nitro-benzoic acid

: 478832-23-4
cis-4-nitrobenzoic acid 4-(1,3-dioxo-1,3-dihydroisoindol-2-yl)cyclohexyl ester

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 20 ℃; for 12h;
DOI:10.1021/jm070270t

Reference yield: 87.0%

: 478832-25-6
2-(cis-4-hydroxycyclohexyl)isoindoline-1,3-dione

: 62-23-7
4-nitro-benzoic acid

: 478832-23-4
cis-4-nitrobenzoic acid 4-(1,3-dioxo-1,3-dihydroisoindol-2-yl)cyclohexyl ester

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 20 ℃; Inert atmosphere;

Reference yield:

: 22509-74-6
N-ethoxycarbonylphthalimide

: 478832-23-4
cis-4-nitrobenzoic acid 4-(1,3-dioxo-1,3-dihydroisoindol-2-yl)cyclohexyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: K₂CO₃ / H₂O / 0.5 h / 20 °C

2: 87 percent / triphenylphosphine; diisopropyl azodicarboxylate / tetrahydrofuran / 12 h / 20 °C

With di-isopropyl azodicarboxylate; potassium carbonate; triphenylphosphine; In tetrahydrofuran; water;
DOI:10.1021/jm070270t