2-Thiophenemethanol,3-amino-(9CI)

Base Information

• Chemical Name: 2-Thiophenemethanol,3-amino-(9CI)
• CAS No.: 170861-45-7
• Molecular Formula: C5H7NOS
• Molecular Weight: 129.182
• Hs Code.: 2934999090
• Mol file: 170861-45-7.mol

Synonyms:2-Thiophenemethanol,3-amino-(9CI);3-Amino-2-(hydroxymethyl)thiophene;3-amino-2-Thiophenemethanol

Chemical Property of 2-Thiophenemethanol,3-amino-(9CI)

Chemical Property:

• Vapor Pressure: 2.01E-05mmHg at 25°C
• Boiling Point: 347.6°C at 760 mmHg
• PKA: 13.75±0.10(Predicted)
• Flash Point: 164°C
• PSA: 74.49000
• Density: 1.359g/cm³
• LogP: 1.40380

Purity/Quality:

98%min ^*data from raw suppliers

(3-Aminothiophen-2-yl)methanol 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Thiophenemethanol,3-amino-(9CI)

There total 1 articles about 2-Thiophenemethanol,3-amino-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

Methyl 3-aminothiophene-2-carboxylate (22288-78-4) → (3-aminothiophen-2-yl)methanol (170861-45-7)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; Inert atmosphere;

DOI:10.1039/b9nj00474b

Reference yield: 93.0%

(3-aminothiophen-2-yl)methanol (170861-45-7) + benzenecarbothioamide (2227-79-4) → 2-phenyl-4H-thieno[3,2-d][1,3]thiazine

Guidance literature:

With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; In ethyl acetate; at 25 ℃; for 0.333333h;

DOI:10.1039/c8ob03058h

Reference yield: 62.0%

(3-aminothiophen-2-yl)methanol (170861-45-7) + acetophenone O-acetyloxime (19433-17-1) → 2-phenyl-5,6,7,8-tetrahydroquinoline

Guidance literature:

With copper diacetate; sodium t-butanolate; In N,N-dimethyl-formamide; at 20 ℃; for 12h;

DOI:10.1039/d0ob02348e

upstream raw materials:

Methyl 3-aminothiophene-2-carboxylate

Downstream raw materials:

C₁₃H₁₃NO₂S

C₂₂H₁₇NO₃S₂

C₁₅H₁₅NO₃S₂

thieno[3,2-b]pyridine-5-carboxylic acid