Ethyl 4-chloro-5,6,7,8-tetrahydroquinoline-3-carboxylate

Base Information

Chemical Name:Ethyl 4-chloro-5,6,7,8-tetrahydroquinoline-3-carboxylate
CAS No.:111205-30-2
Molecular Formula:C12H14ClNO2
Molecular Weight:239.69806
Hs Code.:
DSSTox Substance ID:DTXSID701202464
Mol file:111205-30-2.mol

Synonyms:ethyl 4-chloro-5,6,7,8-tetrahydroquinoline-3-carboxylate;111205-30-2;DKDMXYWZQVIKCI-UHFFFAOYSA-N;SCHEMBL2293526;DTXSID701202464;4-chloro-5,6,7,8-tetrahydro-quinoline-3-carboxylic acid ethyl ester;Ethyl 4-chloro-5,6,7,8-tetrahydro-3-quinolinecarboxylate

Suppliers and Price of Ethyl 4-chloro-5,6,7,8-tetrahydroquinoline-3-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of Ethyl 4-chloro-5,6,7,8-tetrahydroquinoline-3-carboxylate

Chemical Property:

PSA：39.19000
LogP:2.79050
XLogP3:2.9
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:239.0713064
Heavy Atom Count:16
Complexity:259

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CCOC(=O)C1=CN=C2CCCCC2=C1Cl

Technology Process of Ethyl 4-chloro-5,6,7,8-tetrahydroquinoline-3-carboxylate

There total 8 articles about Ethyl 4-chloro-5,6,7,8-tetrahydroquinoline-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 111205-32-4,58596-36-4
4-hydroxy-5,6,7,8-tetrahydro-quinoline-3-carboxylic acid ethyl ester

: 111205-30-2
4-chloro-5,6,7,8-tetrahydro-quinoline-3-carboxylic acid ethyl ester

Guidance literature:: With trichlorophosphate; at 120 ℃; for 1h; Microwave irradiation;

Reference yield:

: ethyl 6,7-dihydro-4-hydroxy-5H-cyclopenta[b]pyridine-3-carboxylate

: 111205-30-2
4-chloro-5,6,7,8-tetrahydro-quinoline-3-carboxylic acid ethyl ester

Guidance literature:: In 4-hydroxy-5,6,7,8-tetrahydro-quinoline-3-carboxylic acid ethyl ester;

Reference yield:

: 6296-99-7
diethyl aminomethylenemalonate

: 111205-30-2
4-chloro-5,6,7,8-tetrahydro-quinoline-3-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 4-toluenesulfonic acid / toluene / Heating

2: diphenyl ether; various solvent(s) / Heating

3: POCl₃ / Heating

With toluene-4-sulfonic acid; trichlorophosphate; In diphenylether; toluene;
DOI:10.1016/j.bmcl.2004.04.085