6296-99-7

Usage

Uses

Used in Organic Synthesis:
DIETHYL AMINOMETHYLENEMALONATE is used as a reagent for the preparation of various organic compounds, contributing to the synthesis of complex molecules and facilitating chemical reactions in the field of organic chemistry.
Used in Pharmaceutical Research:
In the pharmaceutical industry, DIETHYL AMINOMETHYLENEMALONATE is employed as a key component in the development of new drug molecules and active pharmaceutical ingredients, enhancing the discovery and innovation of therapeutic agents.
Used in Medicinal Chemistry:
DIETHYL AMINOMETHYLENEMALONATE is utilized in medicinal chemistry for its potential biological activities, making it a valuable compound in the design and synthesis of novel therapeutic agents with improved efficacy and selectivity.
Overall, DIETHYL AMINOMETHYLENEMALONATE is a significant compound in the realms of organic and medicinal chemistry, playing a crucial role in the synthesis of various organic compounds and the development of innovative pharmaceuticals.

InChI:InChI=1/C8H13NO4/c1-3-12-7(10)6(5-9)8(11)13-4-2/h5H,3-4,9H2,1-2H3

Upstream product

• 98895-14-8 (ethylsulfanyl-methylene)-malonic acid diethyl ester 
• 1117-96-0 Diazoethan 
• 54535-09-0 2-[1-Amino-meth-(E)-ylidene]-malonic acid monoethyl ester 
• 87-13-8 diethyl 2-ethoxymethylenemalonate 
• 17758-33-7 3-methyl-5-nitro-4(3H)-pyrimidinone 
• 105-53-3 diethyl malonate 
• 76369-62-5 4-bromo-3-phenylisoxazol-5(4H)-one 
• 131776-39-1 trimethylsilyl α-bromocyclopropylcarboxylate 
• 54535-14-7 ethyl 5-oxo-2,5-dihydroisoxazole-4-carboxylate 
• 28783-55-3 ethyl 5-ethoxyisoxazole-4-carboxylate 

Downstream Products

• 7251-53-8 ethyl 3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylate 
• 609-08-5 Diethyl methylmalonate 
• 28952-53-6 2-[((Z)-2-Phenyl-propenylamino)-methylene]-malonic acid diethyl ester 
• 58780-88-4 2-(cyclohex-1-enylaminomethylene)-malonic acid diethyl ester 
• 58780-96-4 2-[(2-Methyl-cyclohex-1-enylamino)-methylene]-malonic acid diethyl ester 
• 868363-14-8 2-{[(Z)-1-Methyl-2-(4-nitro-phenyl)-vinylamino]-methylene}-malonic acid diethyl ester 
• 868363-10-4 2-{[(Z)-2-(4-Bromo-phenyl)-1-methyl-vinylamino]-methylene}-malonic acid diethyl ester 
• 868363-12-6 2-{[(Z)-2-(4-Cyano-phenyl)-1-methyl-vinylamino]-methylene}-malonic acid diethyl ester 
• 18617-50-0 1-ethyl-2-pyridone-5-carboxylic acid 
• 3424-43-9 ethyl 2-methyl-6-oxo-1,6-dihydropyridine-3-carboxylate 
• 67677-94-5 2-[((E)-1-Methyl-2-phenyl-vinylamino)-methylene]-malonic acid diethyl ester 
• 111205-30-2 4-chloro-5,6,7,8-tetrahydro-quinoline-3-carboxylic acid ethyl ester 
• 102200-71-5 4-oxo-1,5,7,8-tetrahydro-4H-[1,6]naphthyridine-3,6-dicarboxylic acid diethyl ester 
• 32953-23-4 Ethyl α-ethoxycarbonyl-β-N-(5-benzodioxolyl)-N-ethylaminoacrylate 

Relevant academic research and scientific papers

Discovery of a potent and selective Axl inhibitor in preclinical model

Axl and Mer are a members of the TAM (Tyro3-Axl-Mer) family of receptor tyrosine kinases, which, when activated, can promote tumor cell survival, proliferation, migration, invasion, angiogenesis, and tumor-host interactions. Chronic inhibition of Mer lead

TAM family kinase and/or CSF1R kinase inhibitor and application thereof

The invention provides a novel inhibitor compound shown in a general formula (I). The compound has good kinase inhibition activity and can be used for preventing and/or treating diseases mediated by abnormal expression of TAM family kinase and/or a ligand thereof. The compound can target CSF1R kinase and can be used for preventing and/or treating diseases mediated by abnormal expression of a TAM family kinase receptor and/or a CSF1R kinase receptor and/or ligands thereof.

ORGANIC COMPOUNDS

The invention relates to compound of the formula (I), in which R1 represents an optionally substituted aryl group or an optionally substituted heteroaryl group; R2 represents hydrogen or a substituent different from hydrogen; R3

Simultaneous HPLC analysis of biogenic amines, amino acids, and ammonium ion as aminoenone derivatives in wine and beer samples

A method has been developed for the simultaneous analysis of biogenic amines, amino acids, and the ammonium ion in wine and beer. Aminoenones formed by the reaction of amino acids, biogenic amines, and the ammonium ion with the derivatization reagent diet

Some synthetic approaches to glutamate AMPA receptor agonists based on isoxazolones

Several approaches to the synthesis of derivatives of the antifungal antibiotic TAN-950A, which is also an agonist of glutamate at hippocampal neurons, are reported. Additions of isoxazolon-4-yl anions to methyleneoxazolidinones were not useful because ad

New reactivity of nitropyrimidinone: Ring transformation and N-C transfer reactions

Nitropyrimidinone 1 revealed new reactivity upon treatment with active methylene compounds 2 under basic conditions. The N1-C2-C3-C4 moiety of 1 combined with two carbon units of 2 affording polyfunctionalized pyridones 4, which was hitherto unknown ring transformation. On the other hand, the N1-C2 moiety of 1 was transferred to the methylene group of 2 giving functionalized enamines 3. It was also possible to modify the amino group in 3a by reactions with primary amines. Enamines 3 reacted with hydrazines, and leading to functionalized pyrazoles 7 quantitatively. The ratios of regioisomeric pyrazoles 7/8 were moderately controlled by use of sterically hindered enamines 3h, 3k and 31. Furthermore, enamine 3a was readily converted to 1,4-diazepines 9 having a functional group at the 6-position.

2,5-Dihydropyrazolo[4,3-c]pyridin-3-ones: Functionally selective benzodiazepine binding site ligands on the GABAA receptor

2,5-Dihydropyrazolo[4,3-c]pyridin-3-ones are GABAA receptor benzodiazepine binding site ligands with functional selectivity for the α3 subtype over the α1 subtype. SAR studies to optimise this functional selectivity are described.

Pyrazolo-pyridine derivatives as ligands for GABA receptors

Pyrazolo[4,3-c]pyridin-3-one derivatives substituted at the 2-position by an optionally substituted aryl or heteroaryl moiety, and having pendant substituents at the 7-position and optionally also at the 6-position, are selective ligands for GABAAreceptors, particularly having high affinity for the α2 and/or α3 subunit, and are useful in the treatment and/or prevention of disorders of the central nervous system, including anxiety and convulsions.

4-hydroxyquinoline-3-carboxamides and hydrazides as antiviral agents

The present invention provides 4-hydroxyquinoline-3-carboxamide and hydrazide compounds of formula I These compounds are useful to treat or prevent the herpesviral infections, particularly, human cytomegaloviral infection.

Heterocyclic Synthesis with Azides. I. The Reaction of Hydrazoic Acid with Ethoxymethylenemalonate

Reaction of diethyl ethoxymethylenemalonate with sodium azide in trifluoroacetic acid at 20 deg gives ethyl 5-ethoxyisoxazole-4-carboxylate (67percent), diethyl cyanomalonate (21percent) and diethyl ethoxyaminomethylenmalonate (5percent).The last compound and its tautomer are converted into ethyl 1-ethoxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylate.The product structures have been confirmed by synthesis or degradation.