Hydromorphone hydrochloride

Base Information Edit

Chemical Name:Hydromorphone hydrochloride
CAS No.:71-68-1
Molecular Formula:C17H19NO3.ClH
Molecular Weight:321.804
Hs Code.:2939110000
European Community (EC) Number:200-762-6
UNII:L960UP2KRW
DSSTox Substance ID:DTXSID90991291
Wikidata:Q27106892
NCI Thesaurus Code:C436
RXCUI:203177
ChEMBL ID:CHEMBL1237055
Mol file:71-68-1.mol

Synonyms:Dihydromorphinone;Dilaudid;Hydromorphon;Hydromorphone;Hydromorphone Hydrochloride;Laudacon;Palladone

This product is a nationally controlled contraband, and the Lookchem platform doesn't provide relevant sales information.

Chemical Property of Hydromorphone hydrochloride Edit

Chemical Property:

Vapor Pressure:1.88E-11mmHg at 25°C
Melting Point:>280°C (dec.)
Refractive Index:1.6470 (estimate)
Boiling Point:475.6 °C at 760 mmHg
Flash Point:241.4 °C
PSA：49.77000
Density:1.1451 (rough estimate)
LogP:2.37020
Storage Temp.:2-8°C
Solubility.:H2O: >10 mg/mL
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:0
Exact Mass:321.1131712
Heavy Atom Count:22
Complexity:494

Purity/Quality:

Safty Information:

Pictogram(s): Xn
Hazard Codes:Xn
Statements: 22
Safety Statements: 16-36/37-45

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Canonical SMILES:CN1CCC23C4C1CC5=C2C(=C(C=C5)O)OC3C(=O)CC4.Cl
Isomeric SMILES:CN1CC[C@]23[C@@H]4[C@H]1CC5=C2C(=C(C=C5)O)O[C@H]3C(=O)CC4.Cl
Recent ClinicalTrials:Hydromorphone for Perioperative Analgesia in Lung Tumor Ablation Parallel Controlled
Recent EU Clinical Trials:Efficacy and blood concentrations of epidural hydromorphone in labour
Recent NIPH Clinical Trials:PK study of hydromorphone
Uses Analgesic (narcotic). Preparation by electrolytic reduction of Morphine. Controlled substance (opiate).
Clinical Use Hydromorphone is a potent μ agonist (eight times greater than morphine) that is used to treat severe pain. It is available in intramuscular, intravenous, subcutaneous, oral, and rectal dosage forms. Like all strong μ agonists, hydromorphone is addicting and is a Schedule II drug. Hydromorphone has an oral:parenteral potency ratio of 5:1. The plasma half-lives after parenteral and oral dosage are 2.5 and 4 hours, respectively.
Drug interactions Potentially hazardous interactions with other drugs Alcohol: can cause dose dumping with sustained release preparations. Analgesics: possible opioid withdrawal effects with buprenorphine and pentazocine. Antidepressants: possible CNS excitation or depression with MAOIs - avoid concomitant use and for 2 weeks after stopping MAOI; possible CNS excitation or depression with moclobemide; increased sedative effects with tricyclics. Antihistamines: increased sedative effects with sedating antihistamines. Antipsychotics: enhanced hypotensive and sedative effects. Dopaminergics: avoid with selegiline. Nalmefene: avoid concomitant use. Sodium oxybate: enhanced effect of sodium oxybate - avoid.

Technology Process of Hydromorphone hydrochloride

There total 5 articles about Hydromorphone hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.7%