Hydromorphone hydrochloride

Base Information

• Chemical Name: Hydromorphone hydrochloride
• CAS No.: 71-68-1
• Molecular Formula: C17H19NO3.ClH
• Molecular Weight: 321.804
• Hs Code.: 2939110000
• European Community (EC) Number: 200-762-6
• UNII: L960UP2KRW
• DSSTox Substance ID: DTXSID90991291
• Wikidata: Q27106892
• NCI Thesaurus Code: C436
• RXCUI: 203177
• ChEMBL ID: CHEMBL1237055
• Mol file: 71-68-1.mol

Synonyms:Dihydromorphinone;Dilaudid;Hydromorphon;Hydromorphone;Hydromorphone Hydrochloride;Laudacon;Palladone

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Chemical Property of Hydromorphone hydrochloride

Chemical Property:

• Vapor Pressure: 1.88E-11mmHg at 25°C
• Melting Point: >280°C (dec.)
• Refractive Index: 1.6470 (estimate)
• Boiling Point: 475.6 °C at 760 mmHg
• Flash Point: 241.4 °C
• PSA: 49.77000
• Density: 1.1451 (rough estimate)
• LogP: 2.37020
• Storage Temp.: 2-8°C
• Solubility.: H2O: >10 mg/mL
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 0
• Exact Mass: 321.1131712
• Heavy Atom Count: 22
• Complexity: 494

Purity/Quality:

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22
• Safety Statements: 16-36/37-45

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CN1CCC23C4C1CC5=C2C(=C(C=C5)O)OC3C(=O)CC4.Cl
• Isomeric SMILES: CN1CC[C@]23[C@@H]4[C@H]1CC5=C2C(=C(C=C5)O)O[C@H]3C(=O)CC4.Cl
• Recent ClinicalTrials: Hydromorphone for Perioperative Analgesia in Lung Tumor Ablation Parallel Controlled
• Recent EU Clinical Trials: Efficacy and blood concentrations of epidural hydromorphone in labour
• Recent NIPH Clinical Trials: PK study of hydromorphone
• General Description: Hydromorphone hydrochloride is a potent semisynthetic opioid used for pain management, particularly in cancer patients. It undergoes metabolic transformation in the body, producing various metabolites that are excreted in urine. Understanding its metabolic profile is essential for evaluating its clinical efficacy and safety. The study highlights the importance of analyzing these metabolites to gain insights into hydromorphone's pharmacokinetics and therapeutic implications.

Technology Process of Hydromorphone hydrochloride

There total 5 articles about Hydromorphone hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.7%

hydromorphone (466-99-9) → hydromorphone hydrochloride (71-68-1)

Guidance literature:

With hydrogenchloride; In water; at 45 ℃; Temperature;

Reference yield: 90.0%

Dihydromorphine hydrochloride (1421-28-9) → hydromorphone hydrochloride (71-68-1)

Guidance literature:

With benzophenone; potassium tert-butylate; In toluene; at 85 ℃;

DOI:10.3390/molecules25112640

Reference yield: 75.0%

Hydrocodone (125-29-1) → hydromorphone hydrochloride (71-68-1)

Guidance literature:

With hydrogenchloride; In ethanol; water; at 10 ℃;

upstream raw materials:

Hydrocodone

hydromorphone

Dihydromorphine hydrochloride

(-)-tetrahydrothebaine

Downstream raw materials:

norbinaltorphimine

dihydroisomorphine

5'-(4-chlorophenyl)-6,7-didehydro-4,5α-epoxy-3-hydroxy-17-methylpyrido[2',3':6,7]morphinan

hydromorphone

Refernces

Hydromorphone metabolites: Isolation and identification from pooled urine samples of a cancer patient

10.1080/00498250110119090

The study focused on the isolation and identification of hydromorphone metabolites from the urine samples of a cancer patient undergoing hydromorphone therapy for pain management. Hydromorphone, a potent semisynthetic opioid, was the primary compound of interest, and its metabolites were analyzed to understand its metabolic fate in the human body. The researchers used various chemicals in the study, including hydromorphone hydrochloride, morphine sulfate, Amberlite XAD-2 resin for urine sample processing, and reagents like palladium on activated carbon for synthesis. They also employed LC/MS/MS (liquid chromatography-tandem mass spectrometry) for the detection and identification of metabolites. The purpose of these chemicals was to synthesize known metabolites for comparison with those found in the patient's urine and to develop a method for isolating and identifying hydromorphone and its metabolites. The study aimed to provide a comprehensive profile of hydromorphone metabolism, which is crucial for understanding its efficacy and safety in clinical use.