Technology Process of 2-(2,3-dihydro-[1,4]dioxino[2,3-b]pyridin-6-yl)acetic acid
There total 10 articles about 2-(2,3-dihydro-[1,4]dioxino[2,3-b]pyridin-6-yl)acetic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
water; sodium hydroxide;
In
methanol;
at 20 ℃;
for 1h;
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: caesium carbonate / N,N-dimethyl-formamide / 0 - 90 °C
2.1: sodium hydride; copper; copper(II) sulfate / N,N-dimethyl-formamide; mineral oil / 0 - 100 °C
3.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0 - 20 °C
4.1: 5 h / Reflux
5.1: sodium hydroxide; water / methanol / 1 h / 0 - 20 °C
6.1: manganese(IV) oxide / dichloromethane / 0 - 20 °C
7.1: n-butyllithium / tetrahydrofuran; hexanes / 0.17 h / 0 °C
7.2: 4 h / -78 - 20 °C
8.1: silver nitrate / 60 °C
9.1: sodium hydroxide; water / methanol / 1 h / 20 °C
With
manganese(IV) oxide; n-butyllithium; water; copper; sodium hydride; caesium carbonate; silver nitrate; copper(II) sulfate; 3-chloro-benzenecarboperoxoic acid; sodium hydroxide;
In
tetrahydrofuran; methanol; hexanes; dichloromethane; N,N-dimethyl-formamide; mineral oil;
- Guidance literature:
-
Multi-step reaction with 10 steps
1.1: potassium carbonate / water / 0.5 h / 20 °C
1.2: 4 h / 20 °C
2.1: caesium carbonate / N,N-dimethyl-formamide / 0 - 90 °C
3.1: sodium hydride; copper; copper(II) sulfate / N,N-dimethyl-formamide; mineral oil / 0 - 100 °C
4.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0 - 20 °C
5.1: 5 h / Reflux
6.1: sodium hydroxide; water / methanol / 1 h / 0 - 20 °C
7.1: manganese(IV) oxide / dichloromethane / 0 - 20 °C
8.1: n-butyllithium / tetrahydrofuran; hexanes / 0.17 h / 0 °C
8.2: 4 h / -78 - 20 °C
9.1: silver nitrate / 60 °C
10.1: sodium hydroxide; water / methanol / 1 h / 20 °C
With
manganese(IV) oxide; n-butyllithium; water; copper; sodium hydride; potassium carbonate; caesium carbonate; silver nitrate; copper(II) sulfate; 3-chloro-benzenecarboperoxoic acid; sodium hydroxide;
In
tetrahydrofuran; methanol; hexanes; dichloromethane; water; N,N-dimethyl-formamide; mineral oil;
