2-benzyl-5-chloromethyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-ol

Base Information

• Chemical Name: 2-benzyl-5-chloromethyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-ol
• CAS No.: 1029521-10-5
• Molecular Formula: C₁₃H₁₁ClN₄O
• Molecular Weight: 0
• Mol file: 1029521-10-5.mol

Synonyms:2-benzyl-5-chloromethyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-ol

Chemical Property of 2-benzyl-5-chloromethyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-ol

Chemical Property:

Purity/Quality:

98%min ^*data from raw suppliers

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SDS file from LookChem

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Technology Process of 2-benzyl-5-chloromethyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-ol

There total 2 articles about 2-benzyl-5-chloromethyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

Methyl 4-chloroacetoacetate (32807-28-6,935731-94-5) + 3-benzyl-1H-1,2,4-triazol-5-amine (22819-07-4) → 2-benzyl-5-chloromethyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-ol (1029521-10-5)

Guidance literature:

With acetic acid; at 100 ℃; for 16h;

DOI:10.1016/j.bmcl.2013.11.074

Reference yield:

4-chloro-3-oxobutanoic acid (27807-84-7) + 3-benzyl-1H-1,2,4-triazol-5-amine (22819-07-4) → 2-benzyl-5-chloromethyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-ol (1029521-10-5)

Guidance literature:

With acetic acid; at 80 ℃; for 20h;

Reference yield:

2-benzyl-5-chloromethyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-ol (1029521-10-5) + 3,4-dimethylthiophenol (18800-53-8) → 2-benzyl-5-(3,4-dimethyl-phenylsulfanylmethyl)-[1,2,4]triazolo[1,5-a]pyrimidin-7-ol (1029521-00-3)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In acetonitrile; at 20 ℃; for 16h;

upstream raw materials:

4-chloro-3-oxobutanoic acid

3-benzyl-1H-1,2,4-triazol-5-amine

Methyl 4-chloroacetoacetate

Downstream raw materials:

2-benzyl-5-(3,4-dimethyl-phenylsulfanylmethyl)-[1,2,4]triazolo[1,5-a]pyrimidin-7-ol

2-benzyl-5-phenylsulfanylmethyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-ol

2-benzyl-5-(2,5-dimethyl-furan-3-ylsulfanylmethyl)-[1,2,4]triazolo[1,5-a]pyrimidin-7-ol

2-benzyl-5-(4-chloro-2,5-dimethyl-phenylsulfanylmethyl)-[1,2,4]triazolo[1,5-a]pyrimidin-7-ol

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