Ethyl 2-(2-aminothiazole-4-yl)-2-(1-tert-butoxycarbonyl-1-methylethoxyimino)acetate

Base Information

• Chemical Name: Ethyl 2-(2-aminothiazole-4-yl)-2-(1-tert-butoxycarbonyl-1-methylethoxyimino)acetate
• CAS No.: 86299-46-9
• Molecular Formula: C15H23N3O5S
• Molecular Weight: 357.431
• Hs Code.: 2934100090
• Mol file: 86299-46-9.mol

Synonyms:4-Thiazoleaceticacid, 2-amino-a-[[2-(1,1-dimethylethoxy)-1,1-dimethyl-2-oxoethoxy]imino]-,ethyl ester, (Z)-;

Chemical Property of Ethyl 2-(2-aminothiazole-4-yl)-2-(1-tert-butoxycarbonyl-1-methylethoxyimino)acetate

Chemical Property:

• Appearance/Colour: light beige granular crystalline powder
• Vapor Pressure: 9.56E-09mmHg at 25°C
• Melting Point: 168-174 °C
• Refractive Index: 1.547
• Boiling Point: 462.8 °C at 760 mmHg
• PKA: 1.31±0.10(Predicted)
• Flash Point: 233.7 °C
• PSA: 141.34000
• Density: 1.25 g/cm³
• LogP: 2.71060
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• Water Solubility.: INSOLUBLE

Purity/Quality:

99% ^*data from raw suppliers

Ethyl(Z)-2-(2-aminothiazol-4-yl)-2-(1-t-butoxycarbonyl-1-methyl)ethoxyiminoacetate ^*data from reagent suppliers

Safty Information:

• Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Ethyl 2-(2-aminothiazole-4-yl)-2-(1-tert-butoxycarbonyl-1-methylethoxyimino)acetate

There total 2 articles about Ethyl 2-(2-aminothiazole-4-yl)-2-(1-tert-butoxycarbonyl-1-methylethoxyimino)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl bromoisobutyrate (23877-12-5) + (Z)-ethyl 2-(2-aminothiazol-4-yl)-2-hydroxyiminoacetate (64485-82-1) → ethyl (Z)-2-(2-aminothiazole-4-yl)-2-(2-tert.-butoxycarbonylprop-2-oxyimino) acetate (86299-46-9)

Guidance literature:

With cetyltrimethylammonium chloride; In acetonitrile; at 70 ℃; for 5h; Reagent/catalyst;

Reference yield:

ethyl acetoacetate (141-97-9) → ethyl (Z)-2-(2-aminothiazole-4-yl)-2-(2-tert.-butoxycarbonylprop-2-oxyimino) acetate (86299-46-9)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium nitrite; acetic acid / water / 3.7 h / 20 °C

2.1: sulfuric acid / water; methanol; ethanol / 15 - 20 °C

2.2: 3407 / 2.5 h / 20 - 28 °C

3.1: cetyltrimethylammonium chloride / acetonitrile / 5 h / 70 °C

With sulfuric acid; cetyltrimethylammonium chloride; acetic acid; sodium nitrite; In methanol; ethanol; water; acetonitrile;

upstream raw materials:

tert-butyl bromoisobutyrate

(Z)-ethyl 2-(2-aminothiazol-4-yl)-2-hydroxyiminoacetate

ethyl acetoacetate

Refernces