p-Sulfoaniline-d4

Base Information

• Chemical Name: p-Sulfoaniline-d4
• CAS No.: 1235219-21-2
• Molecular Formula: C₆H₇NO₃S
• Molecular Weight: 177.161
• Mol file: 1235219-21-2.mol

Synonyms:(Aniline-d4)-4-sulfonic Acid;(Aniline-d4)-p-sulfonic Acid;1-AMino-(benzene-d4)-4-sulfonic Acid;4-AMino(benzene-d4)sulfonic Acid;4-AMinophenylsulfonic Acid-d4;4-Sulfoaniline-d4;NSC 7170-d4;p-AMinobenzenesulfonic Acid-d4

Chemical Property of p-Sulfoaniline-d4

Chemical Property:

• PSA: 88.77000
• LogP: 2.17750
• Storage Temp.: Refrigerator, under inert atmosphere
• Solubility.: Aqueous Base (Slightly)

Purity/Quality:

95% ^*data from raw suppliers

SulfanilicAcid-d4 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: p-Sulfoaniline-d4 is the labelled sulfanilic acid (S689095). It is used as Ehrlich’s reagent, for detecting of nitrites. Antibacterial. Labelled Sulfanilic acid (S689095). Sulfanilic acid is a toxic metabolite of Tartrazine (T007700). Used as Ehrlich’s reagent, for detecting of nitrites. Antibacterial.

Technology Process of p-Sulfoaniline-d4

There total 4 articles about p-Sulfoaniline-d4 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

p-acetamidobenzenesulfonyl chloride-d4 (77435-44-0) → p-[(2)H4]-aminobenzene sulfonic acid (1235219-21-2)

Guidance literature:

With water; sodium hydroxide; at 95 ℃; for 3h;

DOI:10.1002/jlcr.1741

Reference yield:

nitrobenzene-d5 (4165-60-0) → p-[(2)H4]-aminobenzene sulfonic acid (1235219-21-2)

Guidance literature:

Multi-step reaction with 4 steps

1: palladium 10% on activated carbon; ammonium formate / methanol / 0.33 h / Inert atmosphere; Reflux

2: 20 °C / Inert atmosphere; Cooling with ice

3: chlorosulfonic acid / 20 °C / Inert atmosphere; Cooling with ice

4: water; sodium hydroxide / 3 h / 95 °C

With chlorosulfonic acid; palladium 10% on activated carbon; water; ammonium formate; sodium hydroxide; In methanol;

DOI:10.1002/jlcr.1741

Reference yield:

aniline-d5 (4165-61-1) → p-[(2)H4]-aminobenzene sulfonic acid (1235219-21-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 20 °C / Inert atmosphere; Cooling with ice

2: chlorosulfonic acid / 20 °C / Inert atmosphere; Cooling with ice

3: water; sodium hydroxide / 3 h / 95 °C

With chlorosulfonic acid; water; sodium hydroxide;

DOI:10.1002/jlcr.1741

upstream raw materials:

p-acetamidobenzenesulfonyl chloride-d₄

nitrobenzene-d5

aniline-d5

acetanilide-d5

Downstream raw materials:

p-[⁽²⁾H₄]-nitrobenzenesulfonic acid

p-[⁽²⁾H₄]-nitrobenzenesulfonyl chloride