METHYL 3-METHYL-5-[4-(TRIFLUOROMETHYL)PHENYL]-2-FUROATE

Base Information

• Chemical Name: METHYL 3-METHYL-5-[4-(TRIFLUOROMETHYL)PHENYL]-2-FUROATE
• CAS No.: 952710-73-5
• Molecular Formula: C14H11F3O3
• Molecular Weight: 284.235
• Mol file: 952710-73-5.mol

Synonyms:METHYL 3-METHYL-5-[4-(TRIFLUOROMETHYL)PHENYL]-2-FUROATE

Chemical Property of METHYL 3-METHYL-5-[4-(TRIFLUOROMETHYL)PHENYL]-2-FUROATE

Chemical Property:

• PSA: 39.44000
• LogP: 4.06040

Purity/Quality:

METHYL-3-METHYL-5-[4-(TRIFLUOROMETHYL)PHENYL]-2-FUROATE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of METHYL 3-METHYL-5-[4-(TRIFLUOROMETHYL)PHENYL]-2-FUROATE

There total 2 articles about METHYL 3-METHYL-5-[4-(TRIFLUOROMETHYL)PHENYL]-2-FUROATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

→ 3-methyl-5-(4-trifluoromethyl-phenyl)-furan-2-carboxylic acid methyl ester (952710-73-5)

Guidance literature:

Reference yield: 57.0%

5-bromo-3-methylfuran-2-carboxylic acid methyl ester (2528-01-0) + 4-trifluoromethylphenylboronic acid (128796-39-4) → 3-methyl-5-(4-trifluoromethyl-phenyl)-furan-2-carboxylic acid methyl ester (952710-73-5)

Guidance literature:

With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; water; Reflux; Inert atmosphere of argon;

Reference yield: 97.0%

3-methyl-5-(4-trifluoromethyl-phenyl)-furan-2-carboxylic acid methyl ester (952710-73-5) → [3-methyl-5-(4-trifluoromethyl-phenyl)-furan-2-yl]-methanol (476155-28-9)

Guidance literature:

3-methyl-5-(4-trifluoromethyl-phenyl)-furan-2-carboxylic acid methyl ester; With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃;

With hydrogenchloride; water; In tetrahydrofuran;

upstream raw materials:

5-bromo-3-methylfuran-2-carboxylic acid methyl ester

4-trifluoromethylphenylboronic acid

Downstream raw materials:

[3-methyl-5-(4-trifluoromethyl-phenyl)-furan-2-yl]-methanol