tert-Butyl 2-((tosyloxy)methyl)morpholine-4-carboxylate

Base Information

• Chemical Name: tert-Butyl 2-((tosyloxy)methyl)morpholine-4-carboxylate
• CAS No.: 130546-33-7
• Molecular Formula: C17H25NO6S
• Molecular Weight: 371.455
• Hs Code.: 2934999090
• DSSTox Substance ID: DTXSID10598701
• Mol file: 130546-33-7.mol

Synonyms:130546-33-7;N-BOC-2-(tosyloxymethyl)morpholine;tert-Butyl 2-((tosyloxy)methyl)morpholine-4-carboxylate;tert-butyl 2-[(4-methylphenyl)sulfonyloxymethyl]morpholine-4-carboxylate;TERT-BUTYL 2-{[(4-METHYLBENZENESULFONYL)OXY]METHYL}MORPHOLINE-4-CARBOXYLATE;tert-Butyl 2-((tosyloxy)methyl)-morpholine-4-carboxylate;4-Morpholinecarboxylic acid, 2-[[[(4-methylphenyl)sulfonyl]oxy]methyl]-, 1,1-dimethylethyl ester;MFCD11044093;SCHEMBL617821;tert-Butyl2-((tosyloxy)methyl)morpholine-4-carboxylate;DTXSID10598701;LOBHRXDXENCDIZ-UHFFFAOYSA-N;MFCD22205724;BS-20452;SY124691;DB-102272;(S)-(4-Boc-morpholin-2-yl)methyl Tosylate;CS-0210945;EN300-7364116;A888706;4-t-butoxycarbonyl-2-(p-toluenesulfonyloxymethyl)morpholine;tert-Butyl 2-{[(4-methylbenzene-1-sulfonyl)oxy]methyl}morpholine-4-carboxylate

Chemical Property of tert-Butyl 2-((tosyloxy)methyl)morpholine-4-carboxylate

Chemical Property:

• PSA: 90.52000
• LogP: 3.35490
• Storage Temp.: 2-8°C
• XLogP3: 2.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 6
• Exact Mass: 371.14025869
• Heavy Atom Count: 25
• Complexity: 543

Purity/Quality:

97% ^*data from raw suppliers

tert-Butyl2-((tosyloxy)methyl)morpholine-4-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC=C(C=C1)S(=O)(=O)OCC2CN(CCO2)C(=O)OC(C)(C)C

Technology Process of tert-Butyl 2-((tosyloxy)methyl)morpholine-4-carboxylate

There total 5 articles about tert-Butyl 2-((tosyloxy)methyl)morpholine-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

p-toluenesulfonyl chloride (98-59-9) + tert-butyl 2-(hydroxymethyl)morpholine-4-carboxylate (135065-69-9) → 4-t-butoxycarbonyl-2-[(4-methylphenylsulphonyloxy)methyl]morpholine (130546-33-7)

Guidance literature:

With pyridine; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 23 ℃; for 18h;

DOI:10.1016/j.bmcl.2008.09.077

Reference yield:

R,S-2-hydroxymethyl-4-benzylmorpholine (40987-24-4,943442-96-4) → 4-t-butoxycarbonyl-2-[(4-methylphenylsulphonyloxy)methyl]morpholine (130546-33-7)

Guidance literature:

Multi-step reaction with 2 steps

1: palladium 10% on activated carbon; hydrogen / methanol / 20 °C

2: triethylamine / dichloromethane / 0 °C

With palladium 10% on activated carbon; hydrogen; triethylamine; In methanol; dichloromethane;

DOI:10.1016/j.bmcl.2014.07.081

Reference yield:

(R)-2-hydroxymethylmorpholine-4-carboxylic acid tert-butyl ester (135065-71-3) → tert-butyl (2R)-2-({[(4-methylphenyl)sulfonyl]oxy}methyl)morpholine-4-carboxylate (135065-64-4) + 4-t-butoxycarbonyl-2-[(4-methylphenylsulphonyloxy)methyl]morpholine (130546-33-7)

Guidance literature:

upstream raw materials:

p-toluenesulfonyl chloride

tert-butyl 2-(hydroxymethyl)morpholine-4-carboxylate

(R)-2-hydroxymethylmorpholine-4-carboxylic acid tert-butyl ester

di-tert-butyl dicarbonate

Downstream raw materials:

C₂₁H₃₂N₂O₅