2-AMINO-4-BROMO-6-METHYLPYRIMIDINE

Base Information

• Chemical Name: 2-AMINO-4-BROMO-6-METHYLPYRIMIDINE
• CAS No.: 5734-71-4
• Molecular Formula: C5H6BrN3
• Molecular Weight: 188.03
• Hs Code.: 2933599090
• Mol file: 5734-71-4.mol

Synonyms:2-AMINO-4-BROMO-6-METHYLPYRIMIDINE;4-broMo-6-MethylpyriMidin-2-aMine

Chemical Property of 2-AMINO-4-BROMO-6-METHYLPYRIMIDINE

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 347.278ºC at 760 mmHg
• Flash Point: 163.828ºC
• PSA: 51.80000
• Density: 1.7g/cm3
• LogP: 1.71090
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

97% ^*data from raw suppliers

2-Amino-4-bromo-6-methylpyrimidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-Amino-4-bromo-6-methylpyrimidine is used in the synthesis of bisphosphonates. As well, in the preparation of heterocyclic phosphonates for pharmaceutical synthesis.

Technology Process of 2-AMINO-4-BROMO-6-METHYLPYRIMIDINE

There total 2 articles about 2-AMINO-4-BROMO-6-METHYLPYRIMIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-amino-6-methyl-3H-pyrimidin-4-one (3977-29-5) → 4-bromo-6-methyl-pyrimidin-2-ylamine (5734-71-4)

Guidance literature:

With phosphorus(V) oxybromide;

DOI:10.1021/jo01166a013

Reference yield:

→ 4-bromo-6-methyl-pyrimidin-2-ylamine (5734-71-4)

Guidance literature:

entspr. Alkohol u. POBr3;

Reference yield: 85.0%

triphenyl phosphite (101-02-0) + 4-bromo-6-methyl-pyrimidin-2-ylamine (5734-71-4) → C17H16N3O3P (1313997-66-8)

Guidance literature:

With amberlyst-15 resin; at 20 ℃; for 0.666667h; neat (no solvent);

DOI:10.1016/j.cclet.2011.01.033

upstream raw materials:

2-amino-6-methyl-3H-pyrimidin-4-one

Downstream raw materials:

C₁₇H₁₆N₃O₃P