(R)-2-HYDROXYMETHYL-PIPERAZINE-2HCl

Base Information

• Chemical Name: (R)-2-HYDROXYMETHYL-PIPERAZINE-2HCl
• CAS No.: 1217482-26-2
• Molecular Formula: C₅H₁₂N₂O*2ClH
• Molecular Weight: 189.085
• Hs Code.: 2933599590
• Mol file: 1217482-26-2.mol

Synonyms:(R)-2-HYDROXYMETHYL-PIPERAZINE-2HCl;BH142;(R)-Piperazin-2-ylMethanol 2HCl;(R)-piperazin-2-ylmethanol dihydrochloride;

Chemical Property of (R)-2-HYDROXYMETHYL-PIPERAZINE-2HCl

Chemical Property:

• PSA: 44.29000
• LogP: 0.80170
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

(R)-Piperazin-2-ylmethanoldihydrochloride 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (R)-2-HYDROXYMETHYL-PIPERAZINE-2HCl

There total 3 articles about (R)-2-HYDROXYMETHYL-PIPERAZINE-2HCl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

4-(phenylmethyl)-2-piperazinemethanol (85817-34-1) → 2-piperazinemethanol dihydrochloride (122323-87-9,149602-65-3,149629-71-0,149629-73-2,1217482-26-2)

Guidance literature:

With hydrogenchloride; hydrogen; palladium on activated charcoal; In tetrahydrofuran; for 2.5h;

DOI:10.1021/jm00067a004

Reference yield:

ethyl 3-oxo-4-(phenylmethyl)-2-piperazinecarboxylate (149648-71-5) → 2-piperazinemethanol dihydrochloride (122323-87-9,149602-65-3,149629-71-0,149629-73-2,1217482-26-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 67 percent / LiAlH₄ / tetrahydrofuran / 1.5 h / Ambient temperature

2: 91 percent / H₂, aq. HCl / 10percent Pd/C / tetrahydrofuran / 2.5 h

With hydrogenchloride; lithium aluminium tetrahydride; hydrogen; palladium on activated charcoal; In tetrahydrofuran;

DOI:10.1021/jm00067a004

Reference yield:

ethyl 3-oxo-1,4-bis(phenylmethyl)-2-piperazinecarboxylate (149648-70-4) → 2-piperazinemethanol dihydrochloride (122323-87-9,149602-65-3,149629-71-0,149629-73-2,1217482-26-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 88 percent / H₂ / 5percent Pd/C / ethanol / 24 h / Ambient temperature

2: 67 percent / LiAlH₄ / tetrahydrofuran / 1.5 h / Ambient temperature

3: 91 percent / H₂, aq. HCl / 10percent Pd/C / tetrahydrofuran / 2.5 h

With hydrogenchloride; lithium aluminium tetrahydride; hydrogen; palladium on activated charcoal; In tetrahydrofuran; ethanol;

DOI:10.1021/jm00067a004

upstream raw materials:

4-(phenylmethyl)-2-piperazinemethanol

ethyl 3-oxo-4-(phenylmethyl)-2-piperazinecarboxylate

ethyl 3-oxo-1,4-bis(phenylmethyl)-2-piperazinecarboxylate

Downstream raw materials:

(1,4-Dinitroso-piperazin-2-yl)-methanol

methyl 3-(hydroxymethyl)-1-piperazinecarboxylate

(S)-methyl 3-(hydroxymethyl)-1-piperazinecarboxylate

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