tert-butyl 4-(hydroxyMethyl)bicyclo[2.2.2]octan-1-ylcarbaMate

Base Information

• Chemical Name: tert-butyl 4-(hydroxyMethyl)bicyclo[2.2.2]octan-1-ylcarbaMate
• CAS No.: 1333384-43-2
• Molecular Formula: C14H25NO3
• Molecular Weight: 255.3532
• Hs Code.: 2924297099
• Mol file: 1333384-43-2.mol

Synonyms:tert-butyl 4-(hydroxyMethyl)bicyclo[2.2.2]octan-1-ylcarbaMate;Carbamic acid, N-[4-(hydroxymethyl)bicyclo[2.2.2]oct-1-yl]-, 1,1-dimethylethyl ester

Chemical Property of tert-butyl 4-(hydroxyMethyl)bicyclo[2.2.2]octan-1-ylcarbaMate

Chemical Property:

• PSA: 58.56000
• LogP: 2.98730

Purity/Quality:

97% ^*data from raw suppliers

tert-Butyl (4-(hydroxymethyl)bicyclo[2.2.2]octan-1-yl)carbamate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of tert-butyl 4-(hydroxyMethyl)bicyclo[2.2.2]octan-1-ylcarbaMate

There total 13 articles about tert-butyl 4-(hydroxyMethyl)bicyclo[2.2.2]octan-1-ylcarbaMate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

4-((tert-butoxycarbonyl)amino)bicyclo[2.2.2]octane-1-carboxylic acid (863304-76-1) → tert-butyl (4-(hydroxymethyl)bicyclo[2.2.2]octane-1-yl)carbamate (1333384-43-2)

Guidance literature:

With borane-THF; In tetrahydrofuran; at 0 - 20 ℃; for 3h;

Reference yield:

(4-aminobicyclo[2.2.2]octan-1-yl)methanol (105176-66-7) + di-tert-butyl dicarbonate (24424-99-5) → tert-butyl (4-(hydroxymethyl)bicyclo[2.2.2]octane-1-yl)carbamate (1333384-43-2)

Guidance literature:

With triethylamine; In dichloromethane; at 4 ℃;

Reference yield:

methyl 4-((tert-butoxycarbonyl)amino)bicyclo[2.2.2]octane-1-carboxylate (943845-74-7) → tert-butyl (4-(hydroxymethyl)bicyclo[2.2.2]octane-1-yl)carbamate (1333384-43-2)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at -70 ℃; for 3h; Inert atmosphere;

upstream raw materials:

dimethyl 1,4-cyclohexane dicarboxylate

dimethyl 1-(2'-chloroethyl)cyclohexane-1,4-dicarboxylate

dimethyl bicyclo[2.2.2]octane-1,4-dicarboxylate

bicyclo[2.2.2]octane-1,4-dicarboxylic acid monomethyl ester