4-(TERT-BUTOXYCARBONYLAMINO)BICYCLO[2.2.2]OCTANE-1-CARBOXYLIC ACID

Base Information

• Chemical Name: 4-(TERT-BUTOXYCARBONYLAMINO)BICYCLO[2.2.2]OCTANE-1-CARBOXYLIC ACID
• CAS No.: 863304-76-1
• Molecular Formula: C₁₄H₂₃NO₄
• Molecular Weight: 269.341
• Hs Code.: 2924299090
• Mol file: 863304-76-1.mol

Synonyms:4-(TERT-BUTOXYCARBONYLAMINO)BICYCLO[2.2.2]OCTANE-1-CARBOXYLIC ACID

Chemical Property of 4-(TERT-BUTOXYCARBONYLAMINO)BICYCLO[2.2.2]OCTANE-1-CARBOXYLIC ACID

Chemical Property:

• Boiling Point: 413.1±44.0 °C(Predicted)
• PKA: 4.88±0.10(Predicted)
• PSA: 79.12000
• Density: 1.17±0.1 g/cm3(Predicted)
• LogP: 2.89310
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

4-((tert-Butoxycarbonyl)amino)bicyclo[2.2.2]octane-1-carboxylic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(TERT-BUTOXYCARBONYLAMINO)BICYCLO[2.2.2]OCTANE-1-CARBOXYLIC ACID

There total 3 articles about 4-(TERT-BUTOXYCARBONYLAMINO)BICYCLO[2.2.2]OCTANE-1-CARBOXYLIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

methyl 4-((tert-butoxycarbonyl)amino)bicyclo[2.2.2]octane-1-carboxylate (943845-74-7) → 4-((tert-butoxycarbonyl)amino)bicyclo[2.2.2]octane-1-carboxylic acid (863304-76-1)

Guidance literature:

With methanol; lithium hydroxide;

Reference yield:

bicyclo[2.2.2]octane-1,4-dicarboxylic acid monomethyl ester (18720-35-9) → 4-((tert-butoxycarbonyl)amino)bicyclo[2.2.2]octane-1-carboxylic acid (863304-76-1)

Guidance literature:

Multi-step reaction with 2 steps

1: diphenyl phosphoryl azide; triethylamine / tert-butyl alcohol / 21 h / 28 °C

2: lithium hydroxide; methanol

With methanol; diphenyl phosphoryl azide; triethylamine; lithium hydroxide; In tert-butyl alcohol;

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → 4-((tert-butoxycarbonyl)amino)bicyclo[2.2.2]octane-1-carboxylic acid (863304-76-1)

Guidance literature:

Multi-step reaction with 2 steps

1: diphenyl phosphoryl azide; triethylamine / tert-butyl alcohol / 21 h / 28 °C

2: lithium hydroxide; methanol

With methanol; diphenyl phosphoryl azide; triethylamine; lithium hydroxide; In tert-butyl alcohol;

upstream raw materials:

bicyclo[2.2.2]octane-1,4-dicarboxylic acid monomethyl ester

di-tert-butyl dicarbonate

methyl 4-((tert-butoxycarbonyl)amino)bicyclo[2.2.2]octane-1-carboxylate

Downstream raw materials:

tert-butyl (4-(hydroxymethyl)bicyclo[2.2.2]octane-1-yl)carbamate

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