4-FLUORO-N-PIPERIDIN-4-YL-BENZAMIDE

Base Information

• Chemical Name: 4-FLUORO-N-PIPERIDIN-4-YL-BENZAMIDE
• CAS No.: 75484-39-8
• Molecular Formula: C12H15FN2O
• Molecular Weight: 222.262
• Hs Code.: 2933399090
• Mol file: 75484-39-8.mol

Synonyms:4-FLUORO-N-PIPERIDIN-4-YL-BENZAMIDE;4-(4-FLUOROBENZAMIDO)PIPERIDINE;OTAVA-BB 1152329;4-[N-(4-Fluorobenzoyl)amino]piperidine

Chemical Property of 4-FLUORO-N-PIPERIDIN-4-YL-BENZAMIDE

Chemical Property:

• Boiling Point: 387.8±37.0 °C(Predicted)
• PKA: 14.23±0.20(Predicted)
• PSA: 41.13000
• Density: 1.18±0.1 g/cm3(Predicted)
• LogP: 2.02720

Purity/Quality:

98%min ^*data from raw suppliers

4-Fluoro-N-(piperidin-4-yl)benzamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-FLUORO-N-PIPERIDIN-4-YL-BENZAMIDE

There total 4 articles about 4-FLUORO-N-PIPERIDIN-4-YL-BENZAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-(1-benzylpiperidin-4-yl)-4-fluorobenzamide (132442-35-4) → N-(piperidin-4-yl)-4-fluorobenzamide (75484-39-8)

Guidance literature:

With ammonium formate; palladium on charcoal; In methanol; water;

Reference yield:

tert-butyl 4-(4-fluorobenzamido)piperidine-1-carboxylate (913634-42-1) → N-(piperidin-4-yl)-4-fluorobenzamide (75484-39-8)

Guidance literature:

With hydrogenchloride; In dichloromethane; ethyl acetate; at 20 ℃; for 2h;

DOI:10.1007/s12272-018-1050-2

Reference yield:

1-(tert-butoxycarbonyl)-4-aminopiperidine (87120-72-7) → N-(piperidin-4-yl)-4-fluorobenzamide (75484-39-8)

Guidance literature:

Multi-step reaction with 2 steps

1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 12.33 h / 0 - 20 °C

2: hydrogenchloride / dichloromethane; ethyl acetate / 2 h / 20 °C

With hydrogenchloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; ethyl acetate;

DOI:10.1007/s12272-018-1050-2

upstream raw materials:

N-(1-benzylpiperidin-4-yl)-4-fluorobenzamide

1-(tert-butoxycarbonyl)-4-aminopiperidine

tert-butyl 4-(4-fluorobenzamido)piperidine-1-carboxylate

4-Fluorobenzoic acid

Downstream raw materials:

4-(4-fluorobenzoylamino)-1-methylsulfonylpiperidine

C₃₂H₃₇FN₄O₂

4-(4-fluorobenzoylamino)-1-(4-trifluoromethoxybenzoyl)piperidine

4-(4-fluorobenzoylamino)-1-methoxycarbonylpiperidine

Refernces

• 1、 -. "2-alkylidene hydroxycumaranone derivatives". . . Retrieved 2008/06/13.