2-(7-Heptadecynyloxy)tetrahydro-2H-pyran

Base Information

• Chemical Name: 2-(7-Heptadecynyloxy)tetrahydro-2H-pyran
• CAS No.: 56599-50-9
• Molecular Formula: C₂₂H₄₀O₂
• Molecular Weight: 336.558
• Mol file: 56599-50-9.mol

Synonyms:2-(7-Heptadecynyloxy)tetrahydro-2H-pyran

Chemical Property of 2-(7-Heptadecynyloxy)tetrahydro-2H-pyran

Chemical Property:

• Vapor Pressure: 1.91E-07mmHg at 25°C
• Boiling Point: 437.5°C at 760 mmHg
• Flash Point: 138.9°C
• PSA: 18.46000
• Density: 0.91g/cm³
• LogP: 6.62420

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(7-Heptadecynyloxy)tetrahydro-2H-pyran

There total 3 articles about 2-(7-Heptadecynyloxy)tetrahydro-2H-pyran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2-[(6-bromohexyl)oxy]tetrahydro-2H-pyran (53963-10-3) + 1-undecyne (2243-98-3) → 2-(7-heptadecynyloxy)tetrahydro-2H-pyran (56599-50-9)

Guidance literature:

1-undecyne; With n-butyllithium; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; hexane; at -60 ℃; for 0.5h;

2-[(6-bromohexyl)oxy]tetrahydro-2H-pyran; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; hexane; at -20 - 20 ℃;

DOI:10.1055/s-0030-1259912

Reference yield:

3,4-dihydro-2H-pyran (110-87-2) → 2-(7-heptadecynyloxy)tetrahydro-2H-pyran (56599-50-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: toluene-4-sulfonic acid / dichloromethane / 20 °C

2.1: n-butyllithium / tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; hexane / 0.5 h / -60 °C

2.2: -20 - 20 °C

With n-butyllithium; toluene-4-sulfonic acid; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; hexane; dichloromethane;

DOI:10.1055/s-0030-1259912

Reference yield:

1-bromo-6-hexanol (4286-55-9) → 2-(7-heptadecynyloxy)tetrahydro-2H-pyran (56599-50-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: toluene-4-sulfonic acid / dichloromethane / 20 °C

2.1: n-butyllithium / tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; hexane / 0.5 h / -60 °C

2.2: -20 - 20 °C

With n-butyllithium; toluene-4-sulfonic acid; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; hexane; dichloromethane;

DOI:10.1055/s-0030-1259912

upstream raw materials:

3,4-dihydro-2H-pyran

2-[(6-bromohexyl)oxy]tetrahydro-2H-pyran

1-undecyne

1-bromo-6-hexanol

Refernces