2-(6-Bromohexyloxy)tetrahydro-2H-pyran

Base Information

• Chemical Name: 2-(6-Bromohexyloxy)tetrahydro-2H-pyran
• CAS No.: 53963-10-3
• Deprecated CAS: 113017-62-2
• Molecular Formula: C11H21BrO2
• Molecular Weight: 265.191
• Hs Code.: 2932999099
• European Community (EC) Number: 258-891-9
• DSSTox Substance ID: DTXSID10886079
• Nikkaji Number: J279.548E
• Mol file: 53963-10-3.mol

Synonyms:2-(6-Bromohexyloxy)tetrahydro-2H-pyran;53963-10-3;2-(6-bromohexoxy)oxane;2-[(6-Bromohexyl)oxy]tetrahydro-2H-pyran;1-Bromo-6-tetrahydropyranyloxyhexane;2H-Pyran, 2-[(6-bromohexyl)oxy]tetrahydro-;2H-Pyran, 2-((6-bromohexyl)oxy)tetrahydro-;EINECS 258-891-9;2-((6-Bromohexyl)oxy)tetrahydro-2H-pyran;2-[(6-bromohexyl)oxy]oxane;SCHEMBL219778;DTXSID10886079;6-tetrahydropyranyloxyhexyl bromide;2-(6'-bromohexyloxy)tetrahydropyran;MFCD00057971;2-(6-bromo-hexyloxy)-tetrahydropyran;AKOS015836204;2-(6-Bromo-hexyloxy)-tetrahydro-pyran;6-bromo-1-(tetrahydropyranyloxy)hexane;(2S)-2-(6-bromohexoxy)tetrahydropyran;1-Tetrahydropyran-2-yloxy-6-bromohexane;2-(6-Bromohexyloxy)tetrahydro-2-H-pyran;BS-50542;1-bromo-6-(2-tetrahydropyranyloxy)-hexane;1-bromo-6-(tetrahydropyran-2-yloxy)-hexane;6-[(Tetrahydropyran-2-yl)oxy]-1bromohexane;CS-0186432;FT-0608708;1-(tetrahydropyran-2-yloxy)-6-hexyl bromide;2H-Pyrane, tetrahydro-2-(6-bromohexyloxy)-;2-(6-Bromohexyloxy)tetrahydro-2H-pyran, 97%;D97413;A829867

Chemical Property of 2-(6-Bromohexyloxy)tetrahydro-2H-pyran

Chemical Property:

• Vapor Pressure: 0.000717mmHg at 25°C
• Melting Point: 90-91℃
• Refractive Index: n20/D 1.478(lit.)
• Boiling Point: 317.4 °C at 760 mmHg
• Flash Point: 127.5 °C
• PSA: 18.46000
• Density: 1.21 g/cm³
• LogP: 3.48490
• Storage Temp.: −20°C
• Solubility.: Chloroform, Dichloromethane, Dimethyl Sulfoxide, Ethyl Acetate
• XLogP3: 3.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 7
• Exact Mass: 264.07249
• Heavy Atom Count: 14
• Complexity: 131

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-(6-Bromohexyloxy)tetrahydro-2H-pyran ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1CCOC(C1)OCCCCCCBr
• Uses: 2-(6-Bromohexyloxy)tetrahydro-2H-pyran may be used as a reactant in the synthesis of diethyl 6-(tetrahydropyran-2-yloxy)hexylphosphonate and 13-(tetrahydo-2H-pyran-2-yloxy)-6-tridecyn-1-ol. 2-(6-Bromohexyloxy)tetrahydro-2H-pyran is an intermediate in the synthesis of (4E, 11Z)-Sphingadienine-C18-1-phosphate which is a sphingoid base of sea cucumber cerebroside that may have cytotoxicity activity against human colon cancer cells.

Technology Process of 2-(6-Bromohexyloxy)tetrahydro-2H-pyran

There total 16 articles about 2-(6-Bromohexyloxy)tetrahydro-2H-pyran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

3,4-dihydro-2H-pyran (110-87-2) + 1-bromo-6-hexanol (4286-55-9) → 2-[(6-bromohexyl)oxy]tetrahydro-2H-pyran (53963-10-3)

Guidance literature:

With camphor-10-sulfonic acid; In dichloromethane; at 0 ℃; for 2h;

DOI:10.1021/ol034700v

Reference yield: 93.0%

dihydropyran (3174-74-1) + 1-bromo-6-hexanol (4286-55-9) → 2-[(6-bromohexyl)oxy]tetrahydro-2H-pyran (53963-10-3)

Guidance literature:

With toluene-4-sulfonic acid; In dichloromethane; at 20 ℃;

Reference yield: 89.0%

TETRAHYDROPYRANE (142-68-7) + 1-bromo-6-hexanol (4286-55-9) → 2-[(6-bromohexyl)oxy]tetrahydro-2H-pyran (53963-10-3)

Guidance literature:

With pyridinium p-toluenesulfonate; In dichloromethane; at 20 ℃; for 3h; Inert atmosphere;

DOI:10.1002/pola.26339

upstream raw materials:

3,4-dihydro-2H-pyran

1-bromo-6-hexanol

(chloro-6' hexyloxy)-2 tetrahydropyranne

2-hexyloxy-tetrahydro-pyran

Downstream raw materials:

1-(2-tetrahydropyranyloxy)-9E-tetradecene

(6-bromohexyloxy)-tert-butyldimethylsilane

N,N'-bis<6-(2-tetrahydropyranyloxy)hexyl>-N,N'-di-p-toluenesulfonyl-1,6-hexanediamine

1-(2-Tetrahydropyranyloxy)-7-octyne