1-Hydroxy-4-methylcyclohexane-1-carboxylic acid

Base Information

• Chemical Name: 1-Hydroxy-4-methylcyclohexane-1-carboxylic acid
• CAS No.: 41248-15-1
• Molecular Formula: C₈H₁₄O₃
• Molecular Weight: 158.197
• European Community (EC) Number: 817-205-3
• Mol file: 41248-15-1.mol

Synonyms:1-hydroxy-4-methylcyclohexane-1-carboxylic acid;41248-15-1;1-hydroxy-4-methylcyclohexanecarboxylic acid;SCHEMBL3529212;MFCD14601959;AKOS010487145;BS-12432;1-hydroxy-4-methylcyclohexanecarboxylicacid;CS-0222482;EN300-111302;Z787969972

Chemical Property of 1-Hydroxy-4-methylcyclohexane-1-carboxylic acid

Chemical Property:

• XLogP3: 1
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 158.094294304
• Heavy Atom Count: 11
• Complexity: 157

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1CCC(CC1)(C(=O)O)O

Technology Process of 1-Hydroxy-4-methylcyclohexane-1-carboxylic acid

There total 13 articles about 1-Hydroxy-4-methylcyclohexane-1-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-hydroxy-4-methyl-cyclohexanecarboxylic acid-(4-methyl-cyclohex-1-enyl ester) (94092-43-0) → 1-hydroxy-4-methyl-cyclohexanecarboxylic acid (41248-15-1) + 1-methylcyclohexan-4-one (589-92-4)

Guidance literature:

With potassium hydroxide; substance of mp: 82 degree;

DOI:10.1007/PL00009877 DOI:10.1039/jr9640001413

Reference yield:

1-methylcyclohexan-4-one (589-92-4) → 1-hydroxy-4-methyl-cyclohexanecarboxylic acid (41248-15-1)

Guidance literature:

Multi-step reaction with 2 steps

1: aqueous sodium hydrogen sulfite solution / anschliessend Behandeln mit wss. Kaliumcyanid-Loesung

2: aqueous hydrochloric acid

With hydrogenchloride; sodium hydrogensulfite;

Reference yield:

1-hydroxy-4-methyl-cyclohexanecarbonitrile (933-45-9) → 1-hydroxy-4-methyl-cyclohexanecarboxylic acid (41248-15-1)

Guidance literature:

With hydrogenchloride; substances of mp: 130 degree , of mp: 122 degree , and of mp: 95 degree;

DOI:10.1039/jr9350000474

upstream raw materials:

1-hydroxy-4-methyl-cyclohexanecarboxylic acid-(4-methyl-cyclohex-1-enyl ester)

1-amino-4-methyl-cyclohexanecarboxylic acid

1-hydroxy-4-methyl-cyclohexanecarboxylic acid anilide

1-hydroxy-4-methyl-cyclohexanecarbonitrile

Downstream raw materials:

1-methylcyclohexan-4-one

4-methylcyclohex-1-ene-1-carboxylic acid

3-p-menthene

p-menthane-4-ol

Refernces