1H-PYRAZOLE, 1-[(4-FLUOROPHENYL)METHYL]-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-

Base Information

• Chemical Name: 1H-PYRAZOLE, 1-[(4-FLUOROPHENYL)METHYL]-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-
• CAS No.: 1379615-58-3
• Molecular Formula: C₁₆H₂₀BFN₂O₂
• Molecular Weight: 302.156
• Mol file: 1379615-58-3.mol

Synonyms:1H-PYRAZOLE, 1-[(4-FLUOROPHENYL)METHYL]-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-;1-(4-fluorobenzyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole

Chemical Property of 1H-PYRAZOLE, 1-[(4-FLUOROPHENYL)METHYL]-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-PYRAZOLE, 1-[(4-FLUOROPHENYL)METHYL]-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-

There total 6 articles about 1H-PYRAZOLE, 1-[(4-FLUOROPHENYL)METHYL]-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

4-bromo-1-(4-fluorobenzyl)-1H-pyrazole (251925-14-1) + bis(pinacol)diborane (73183-34-3) → 1‐(4‐fluorobenzyl)‐4‐(4,4,5,5‐tetramethyl‐1,3,2-dioxaborolan‐2‐yl)-1H‐pyrazole (1379615-58-3)

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; In dimethyl sulfoxide; at 100 ℃; for 11h; Inert atmosphere;

Reference yield: 90.2%

4-((4-iodo-1H-pyrazol-1-yl)methyl)benzonitrile + bis(pinacol)diborane (73183-34-3) → 1‐(4‐fluorobenzyl)‐4‐(4,4,5,5‐tetramethyl‐1,3,2-dioxaborolan‐2‐yl)-1H‐pyrazole (1379615-58-3)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; potassium acetate; In N,N-dimethyl-formamide; at 85 ℃; for 24h; Inert atmosphere;

Reference yield: 83.9%

→ 1‐(4‐fluorobenzyl)‐4‐(4,4,5,5‐tetramethyl‐1,3,2-dioxaborolan‐2‐yl)-1H‐pyrazole (1379615-58-3)

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; In dimethyl sulfoxide; at 105 ℃; for 17h; Inert atmosphere;

upstream raw materials:

pyrazole-4-boronic acid pinacol ester

4-Fluorobenzyl bromide

4-bromo-1-(4-fluorobenzyl)-1H-pyrazole

bis(pinacol)diborane

Downstream raw materials:

3-(1-(4-fluorobenzyl)-1H-pyrazol-4-yl)-5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine

C₂₈H₂₃FN₆O₂S

5-bromo-3-(1-(4-fluorobenzyl)-1H-pyrazol-4-yl)-1-tosyl-1H-pyrrolo[2,3-b]pyridine