methyl 2-[(2-{[tert-butyl(dimethyl)silyl]oxy}ethyl)thio]benzoate

Base Information

Chemical Name:methyl 2-[(2-{[tert-butyl(dimethyl)silyl]oxy}ethyl)thio]benzoate
CAS No.:1344738-24-4
Molecular Formula:C₁₆H₂₆O₃SSi
Molecular Weight:0
Hs Code.:
Mol file:1344738-24-4.mol

Synonyms:methyl 2-[(2-{[tert-butyl(dimethyl)silyl]oxy}ethyl)thio]benzoate

Suppliers and Price of methyl 2-[(2-{[tert-butyl(dimethyl)silyl]oxy}ethyl)thio]benzoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 2 raw suppliers

Chemical Property of methyl 2-[(2-{[tert-butyl(dimethyl)silyl]oxy}ethyl)thio]benzoate

Chemical Property:

Purity/Quality:: 98%min ^*data from raw suppliers

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Technology Process of methyl 2-[(2-{[tert-butyl(dimethyl)silyl]oxy}ethyl)thio]benzoate

There total 1 articles about methyl 2-[(2-{[tert-butyl(dimethyl)silyl]oxy}ethyl)thio]benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 86864-60-0
2-(tert-butyldimethylsilyloxy)ethyl bromide

: 4892-02-8
Methyl thiosalicylate

: 1344738-24-4
methyl 2-[(2-{[tert-butyl(dimethyl)silyl]oxy}ethyl)thio]benzoate

Guidance literature:: Methyl thiosalicylate; With sodium hydride; In N,N-dimethyl-formamide; for 1h; Inert atmosphere;

2-(tert-butyldimethylsilyloxy)ethyl bromide; In N,N-dimethyl-formamide; at 20 ℃; Inert atmosphere;
DOI:10.1021/jm200677b

Reference yield: 81.0%

: 1344738-24-4
methyl 2-[(2-{[tert-butyl(dimethyl)silyl]oxy}ethyl)thio]benzoate

: 1344738-25-5
{2-[(2-{[tert-butyl(dimethyl)silyl]oxy}ethyl)thio]phenyl}methanol

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃; Inert atmosphere;
DOI:10.1021/jm200677b

Reference yield:

: 1344738-24-4
methyl 2-[(2-{[tert-butyl(dimethyl)silyl]oxy}ethyl)thio]benzoate

: C₂₈H₃₅N₃O₄S₃Si

Guidance literature:: Multi-step reaction with 6 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

2.1: barium permanganate / dichloromethane / 24 h / 20 °C / Inert atmosphere

2.2: Reflux; Inert atmosphere

3.1: ethanol / 3 h / Reflux; Inert atmosphere

4.1: [bis(acetoxy)iodo]benzene / methanol; dichloromethane / 20 °C / Inert atmosphere

5.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; caesium carbonate / N,N-dimethyl-formamide / 4 h / 90 °C / Inert atmosphere

6.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 20 °C / Inert atmosphere

With lithium aluminium tetrahydride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; barium permanganate; [bis(acetoxy)iodo]benzene; caesium carbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm200677b