1-{2-[(3-{2-[(2-{[tert-butyl(dimethyl)silyl]oxy}ethyl)thio]phenyl}[1,2,4]triazolo[4,3-a]pyridin-6-yl)thio]benzyl}-3-{1-(3-chloro-4-hydroxyphenyl)-3-[1,1-dimethyl-2-(methylthio)ethyl]-1H-pyrazol-5-yl}urea

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Chemical Name:1-{2-[(3-{2-[(2-{[tert-butyl(dimethyl)silyl]oxy}ethyl)thio]phenyl}[1,2,4]triazolo[4,3-a]pyridin-6-yl)thio]benzyl}-3-{1-(3-chloro-4-hydroxyphenyl)-3-[1,1-dimethyl-2-(methylthio)ethyl]-1H-pyrazol-5-yl}urea
CAS No.:1344738-30-2
Molecular Formula:C₄₂H₅₀ClN₇O₃S₃Si
Molecular Weight:860.641
Hs Code.:

1-{2-[(3-{2-[(2-{[tert-butyl(dimethyl)silyl]oxy}ethyl)thio]phenyl}[1,2,4]triazolo[4,3-a]pyridin-6-yl)thio]benzyl}-3-{1-(3-chloro-4-hydroxyphenyl)-3-[1,1-dimethyl-2-(methylthio)ethyl]-1H-pyrazol-5-yl}urea

Synonyms:1-{2-[(3-{2-[(2-{[tert-butyl(dimethyl)silyl]oxy}ethyl)thio]phenyl}[1,2,4]triazolo[4,3-a]pyridin-6-yl)thio]benzyl}-3-{1-(3-chloro-4-hydroxyphenyl)-3-[1,1-dimethyl-2-(methylthio)ethyl]-1H-pyrazol-5-yl}urea

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Chemical Property of 1-{2-[(3-{2-[(2-{[tert-butyl(dimethyl)silyl]oxy}ethyl)thio]phenyl}[1,2,4]triazolo[4,3-a]pyridin-6-yl)thio]benzyl}-3-{1-(3-chloro-4-hydroxyphenyl)-3-[1,1-dimethyl-2-(methylthio)ethyl]-1H-pyrazol-5-yl}urea

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Technology Process of 1-{2-[(3-{2-[(2-{[tert-butyl(dimethyl)silyl]oxy}ethyl)thio]phenyl}[1,2,4]triazolo[4,3-a]pyridin-6-yl)thio]benzyl}-3-{1-(3-chloro-4-hydroxyphenyl)-3-[1,1-dimethyl-2-(methylthio)ethyl]-1H-pyrazol-5-yl}urea

There total 17 articles about 1-{2-[(3-{2-[(2-{[tert-butyl(dimethyl)silyl]oxy}ethyl)thio]phenyl}[1,2,4]triazolo[4,3-a]pyridin-6-yl)thio]benzyl}-3-{1-(3-chloro-4-hydroxyphenyl)-3-[1,1-dimethyl-2-(methylthio)ethyl]-1H-pyrazol-5-yl}urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 27.0%

: 1344738-28-8
phenyl {1-(4-{[tert-butyl(dimethyl)silyl]oxy}-3-chlorophenyl)-3-[1,1-dimethyl-2-(methylthio)ethyl]-1H-pyrazol-5-yl}carbamate

: 1344738-18-6
1-{2-[(3-{2-[(2-{[tert-butyl(dimethyl)silyl]oxy}ethyl)thio]-phenyl}[1,2,4]triazolo[4,3-a]pyridin-6-yl)thio]phenyl}methanamine

: 1344738-30-2
1-{2-[(3-{2-[(2-{[tert-butyl(dimethyl)silyl]oxy}ethyl)thio]phenyl}[1,2,4]triazolo[4,3-a]pyridin-6-yl)thio]benzyl}-3-{1-(3-chloro-4-hydroxyphenyl)-3-[1,1-dimethyl-2-(methylthio)ethyl]-1H-pyrazol-5-yl}urea

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dimethyl sulfoxide; at 20 ℃; for 16h; Inert atmosphere;
DOI:10.1021/jm200677b

Reference yield:

: 876299-32-0
4,4-dimethyl-5-(methylthio)-3-oxopentanenitrile

: 1344738-30-2
1-{2-[(3-{2-[(2-{[tert-butyl(dimethyl)silyl]oxy}ethyl)thio]phenyl}[1,2,4]triazolo[4,3-a]pyridin-6-yl)thio]benzyl}-3-{1-(3-chloro-4-hydroxyphenyl)-3-[1,1-dimethyl-2-(methylthio)ethyl]-1H-pyrazol-5-yl}urea

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogenchloride / ethanol; water / 6 h / Reflux; Inert atmosphere

2: 1H-imidazole / N,N-dimethyl-formamide / 16 h / 20 °C / Inert atmosphere

3: pyridine / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

4: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 16 h / 20 °C / Inert atmosphere

With pyridine; 1H-imidazole; hydrogenchloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; ethanol; water; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/jm200677b

Reference yield:

: 1344738-24-4
methyl 2-[(2-{[tert-butyl(dimethyl)silyl]oxy}ethyl)thio]benzoate

: 1344738-30-2
1-{2-[(3-{2-[(2-{[tert-butyl(dimethyl)silyl]oxy}ethyl)thio]phenyl}[1,2,4]triazolo[4,3-a]pyridin-6-yl)thio]benzyl}-3-{1-(3-chloro-4-hydroxyphenyl)-3-[1,1-dimethyl-2-(methylthio)ethyl]-1H-pyrazol-5-yl}urea

Guidance literature:: Multi-step reaction with 8 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

2.1: barium permanganate / dichloromethane / 24 h / 20 °C / Inert atmosphere

2.2: Reflux; Inert atmosphere

3.1: ethanol / 3 h / Reflux; Inert atmosphere

4.1: [bis(acetoxy)iodo]benzene / methanol; dichloromethane / 20 °C / Inert atmosphere

5.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; caesium carbonate / N,N-dimethyl-formamide / 4 h / 90 °C / Inert atmosphere

6.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 20 °C / Inert atmosphere

7.1: ammonia / methanol / 4 h / Inert atmosphere

8.1: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 16 h / 20 °C / Inert atmosphere

With lithium aluminium tetrahydride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; barium permanganate; [bis(acetoxy)iodo]benzene; ammonia; caesium carbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; ethanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/jm200677b