2-Bromo-3-fluoro-4-methoxypyridine

Base Information

• Chemical Name: 2-Bromo-3-fluoro-4-methoxypyridine
• CAS No.: 109613-98-1
• Molecular Formula: C6H5BrFNO
• Molecular Weight: 206.014
• Hs Code.: 2933399990
• European Community (EC) Number: 823-625-8
• Mol file: 109613-98-1.mol

Synonyms:2-Bromo-3-fluoro-4-methoxypyridine;109613-98-1;MFCD18257613;Pyridine, 2-bromo-3-fluoro-4-methoxy-;SCHEMBL17785361;BS-26057;SY068091;CS-0180944;EN300-263850;H11794

Chemical Property of 2-Bromo-3-fluoro-4-methoxypyridine

Chemical Property:

• PSA: 22.12000
• LogP: 1.99180
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• XLogP3: 1.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 204.95385
• Heavy Atom Count: 10
• Complexity: 114

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Bromo-3-fluoro-4-methoxypyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=C(C(=NC=C1)Br)F

Technology Process of 2-Bromo-3-fluoro-4-methoxypyridine

There total 2 articles about 2-Bromo-3-fluoro-4-methoxypyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-methoxypyridin-3-amine (33631-09-3) → 2-bromo-3-fluoro-4-methoxypyridine (109613-98-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / Br₂, conc. HCl / 1 h

With hydrogenchloride; bromine;

Reference yield:

2-bromo-4-methoxy-pyridin-3-amine (109613-97-0) → 2-bromo-3-fluoro-4-methoxypyridine (109613-98-1)

Guidance literature:

Yield given. Multistep reaction;

Reference yield: 12.0%

copper(l) cyanide + 2-bromo-3-fluoro-4-methoxypyridine (109613-98-1) → 3-fluoro-4-methoxypyridine-2-carbonitrile (1427357-47-8)

Guidance literature:

In N,N-dimethyl-formamide; at 100 ℃; for 16h; Sealed tube; Inert atmosphere;

upstream raw materials:

2-bromo-4-methoxy-pyridin-3-amine

4-methoxypyridin-3-amine

Downstream raw materials:

orelline

3,3',4,4'-tetrahydroxy-2,2'-bipyridine-1,1'-dioxide

3-fluoro-4-methoxypyridine-2-carbonitrile