5-(2-(Benzyloxy)ethyl)-1-(4-chloro-2-nitrophenyl)-1H-pyrazole

Base Information

• Chemical Name: 5-(2-(Benzyloxy)ethyl)-1-(4-chloro-2-nitrophenyl)-1H-pyrazole
• CAS No.: 1357561-15-9
• Molecular Formula: C18H16ClN3O3
• Molecular Weight: 357.79094
• Hs Code.: 2933199090
• Mol file: 1357561-15-9.mol

Synonyms:5-(2-(Benzyloxy)ethyl)-1-(4-chloro-2-nitrophenyl)-1H-pyrazole

Chemical Property of 5-(2-(Benzyloxy)ethyl)-1-(4-chloro-2-nitrophenyl)-1H-pyrazole

Chemical Property:

• PSA: 72.87000
• LogP: 4.71640

Purity/Quality:

5-(2-(Benzyloxy)ethyl)-1-(4-chloro-2-nitrophenyl)-1H-pyrazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-(2-(Benzyloxy)ethyl)-1-(4-chloro-2-nitrophenyl)-1H-pyrazole

There total 5 articles about 5-(2-(Benzyloxy)ethyl)-1-(4-chloro-2-nitrophenyl)-1H-pyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 19.0%

(4-chloro-2-nitrophenyl)hydrazine hydrochloride (100032-77-7) + 5-(benzyloxy)-1-(methoxy(methyl)amino)pent-1-en-3-one (1357561-14-8) → 5-(2-(benzyloxy)ethyl)-1-(4-chloro-2-nitrophenyl)-1H-pyrazole (1357561-15-9) + C18H16ClN3O3

Guidance literature:

With sodium carbonate; In methanol; water; at 0 ℃; for 1.5h; Reflux;

DOI:10.1002/jhet.878

Reference yield:

3-(benzyloxy)-N-methoxy-N-methylpropanamide (1004112-07-5) → 5-(2-(benzyloxy)ethyl)-1-(4-chloro-2-nitrophenyl)-1H-pyrazole (1357561-15-9) + C18H16ClN3O3

Guidance literature:

Multi-step reaction with 2 steps

1.1: tetrahydrofuran / 0.67 h / 50 °C

1.2: 0.67 h / 50 °C

2.1: sodium carbonate / methanol; water / 1.5 h / 0 °C / Reflux

With sodium carbonate; In tetrahydrofuran; methanol; water;

DOI:10.1002/jhet.878

Reference yield:

3-benzyloxypropan-1-ol (4799-68-2) → 5-(2-(benzyloxy)ethyl)-1-(4-chloro-2-nitrophenyl)-1H-pyrazole (1357561-15-9) + C18H16ClN3O3

Guidance literature:

Multi-step reaction with 4 steps

1.1: Jones reagent / acetone / 2.75 h / 0 °C

2.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 72 h / 20 °C

3.1: tetrahydrofuran / 0.67 h / 50 °C

3.2: 0.67 h / 50 °C

4.1: sodium carbonate / methanol; water / 1.5 h / 0 °C / Reflux

With Jones reagent; sodium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; acetone; 1.1: Jones oxidation;

DOI:10.1002/jhet.878

upstream raw materials:

3-(benzyloxy)-N-methoxy-N-methylpropanamide

(4-chloro-2-nitrophenyl)hydrazine hydrochloride

5-(benzyloxy)-1-(methoxy(methyl)amino)pent-1-en-3-one

3-benzyloxypropan-1-ol

Downstream raw materials:

8-chloro-6-phenyl-5,6-dihydro-4H-benzo[b]pyrazolo[1,5-d][1,4]diazepine

8-chloro-6-phenyl-4H-benzo[b]pyrazolo[1,5-d][1,4]diazepin-5(6H)-one

5-chloro-2-(5-(2-chloroethyl)-1H-pyrazol-1-yl)aniline

2-(1-(2-amino-4-chlorophenyl)-1H-pyrazol-5-yl)ethanol

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