100032-77-7

Usage

Uses

Used in Organic Synthesis:
(4-chloro-2-nitrophenyl)hydrazine hydrochloride is used as a key intermediate in the synthesis of various organic compounds. Its unique structure facilitates multiple reaction pathways, contributing to the creation of a diverse range of chemical products.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, (4-chloro-2-nitrophenyl)hydrazine hydrochloride is used as a building block for the development of new drugs. Its anti-tumor and anti-bacterial properties make it a promising candidate for the treatment of various diseases, particularly those related to cancer and bacterial infections.
Used as a Spectroscopic Reagent:
(4-chloro-2-nitrophenyl)hydrazine hydrochloride is employed as a spectrophotometric reagent for the determination of certain metal ions. Its ability to form complexes with metal ions allows for the quantitative analysis of these elements in various samples, which is crucial in fields such as environmental monitoring, materials science, and chemical research.
Used in Research and Development:
(4-chloro-2-nitrophenyl)hydrazine hydrochloride is also used in research and development for the discovery of new chemical reactions and the synthesis of novel molecules with potential applications in various industries, including pharmaceuticals, agrochemicals, and materials science.
Safety Precautions:
It is important to handle (4-chloro-2-nitrophenyl)hydrazine hydrochloride with care, as it is considered hazardous if ingested or inhaled and can cause irritation to the skin and eyes. Proper safety measures, including the use of personal protective equipment and adherence to safety protocols, should be followed to minimize the risk of exposure and potential health hazards.

Upstream product

• 89-63-4 4-Chloro-2-nitroaniline 

Downstream Products

• 1120344-80-0 2-[(4-chloro-2-nitrophenyl)hydrazono]propionic acid methyl ester 
• 1357561-15-9 5-(2-(benzyloxy)ethyl)-1-(4-chloro-2-nitrophenyl)-1H-pyrazole 
• 1357561-12-6 8-chloro-6-phenyl-5,6-dihydro-4H-benzo[b]pyrazolo[1,5-d][1,4]diazepine 
• 1357561-13-7 8-chloro-6-phenyl-4H-benzo[b]pyrazolo[1,5-d][1,4]diazepin-5(6H)-one 
• 1357561-19-3 5-chloro-2-(5-(2-chloroethyl)-1H-pyrazol-1-yl)aniline 
• 1357561-16-0 2-(1-(2-amino-4-chlorophenyl)-1H-pyrazol-5-yl)ethanol 

Relevant academic research and scientific papers

Rational Design, Synthesis and Evaluation of Indole Nitrogen Hybrids as Photosystem II Inhibitors

We report the synthesis of twelve indole derivatives bearing nitro or amide groups via Fischer indole methodology followed by reduction/acetylation and amidation reactions. After thorough characterization, these indoles were subjected to a number of studies in order to evaluate their bioactive potential as photosynthesis and plant growth inhibitors. Firstly, these molecular hybrids were evaluated as photosystem II (PSII) inhibitors through chlorophyll a (Chl a) fluorescence measurement. In this study, 6-chloro-8-nitro-2,3,4,9-tetrahydro-1H-carbazole (15a) and 5-chloro-2,3-dimethyl-7-nitro-1H-indole (15b) showed the best results by reducing the phenomenological parameters of reaction centers ABS/RC, TR0/RC and ET0/RC of PSII. Electron chain blockage by these compounds may lead to diminished ATP synthesis and CO2 fixation which interrupt the plant development. The compounds 15a and 15b both act as postemergent herbicides, reducing the dry biomass of Ipomoea grandifolia and Senna alata weeds by an average of 40% and 37%, respectively, corroborating the fluorescence results. Additionally, the molecular docking study revealed that the presence of strong electron-withdrawing groups at the indole phenyl ring is important for the ligand’s interaction with the binding pocket of protein D1 on PSII. The optimization of these molecular features is the goal of our research group in further understanding and development of new potent herbicides.

INDOLEAMIDE COMPOUNDS AS AN IHNIBITOR OF CELLULAR NECROSIS

The present invention relates to a an indoleamide compound of chemical formula 1, pharmaceutically allowable salt thereof, or an isomer, to a composition for preventing or treating cellular necrosis and related diseases containing the same as an active in

Synthesis of novel benzo[b]pyrazolo[1,5]diazepines

The synthesis and in vitro biological evaluation of two novel benzodiazepine derivatives are described. The compounds were synthesized divergently from the key amino alcohol 5, which was realized using the unusual Weinreb-enamino ketone 10..

GLUCOKINASE ACTIVATORS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME AS AN ACTIVE INGREDIENT

The present invention relates to new compounds of formula (1) exhibiting excellent activity for glucokinase, and pharmaceutical compositions comprising the same as an active ingredient.

INDOLE COMPOUNDS AS AN INHIBITOR OF CELLULAR NECROSIS

The present invention relates to new indole compounds, pharmaceutically acceptable salts or isomers thereof which are useful for the prevention or treatment of cellular necrosis and necrosis-associated diseases. The present invention also relates to a method and a composition for the prevention or treatment of cellular necrosis and necrosis-associated diseases, comprising said indole compounds as an active ingredient.

GLUCOKINASE ACTIVATORS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME AS AN ACTIVE INGREDIENT

The present invention relates to new compounds of formula (1) exhibiting excellent activity for glucokinase, and pharmaceutical compositions comprising the same as an active ingredient.