N-BOC-L-VALINYL-L-LEUCINYL N-HYDROXYSUCCINIMIDE ESTER

Base Information

• Chemical Name: N-BOC-L-VALINYL-L-LEUCINYL N-HYDROXYSUCCINIMIDE ESTER
• CAS No.: 84642-33-1
• Molecular Formula: C₂₀H₃₃N₃O₇
• Molecular Weight: 427.498
• Mol file: 84642-33-1.mol

Synonyms:N-BOC-L-VALINYL-L-LEUCINYL N-HYDROXYSUCCINIMIDE ESTER;N-Boc-Val-L-leu-NHS;1-[[N-[N-[(1,1-DiMethylethoxy)carbonyl]-L-valyl]-L-leucyl]oxy]-2,5-pyrrolidinedione

Chemical Property of N-BOC-L-VALINYL-L-LEUCINYL N-HYDROXYSUCCINIMIDE ESTER

Chemical Property:

• PSA: 131.11000
• Density: 1.189g/cm³
• LogP: 2.39350
• Solubility.: Chloroform, Dichloromethane, DMF, DMSO, Ethyl Acetate

Purity/Quality:

97% ^*data from raw suppliers

N-Boc-L-valinyl-L-leucinyl N-Hydroxysuccinimide Ester ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-BOC-L-VALINYL-L-LEUCINYL N-HYDROXYSUCCINIMIDE ESTER

There total 5 articles about N-BOC-L-VALINYL-L-LEUCINYL N-HYDROXYSUCCINIMIDE ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

1-hydroxy-pyrrolidine-2,5-dione (6066-82-6) + (2S)-2-(2-(tert-butoxycarbonylamino)-3-methylbutanamido)-4-methylpentanoic acid (27506-15-6) → Nα-Boc-Val-Leu N-hydroxysuccinimide ester (84642-33-1)

Guidance literature:

With dicyclohexyl-carbodiimide; In dichloromethane; at 0 ℃; for 6h;

DOI:10.1021/jm00359a004

Reference yield:

t-Boc-L-valine (13734-41-3) → Nα-Boc-Val-Leu N-hydroxysuccinimide ester (84642-33-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 88 percent / N-methylmorpholine, 1-hydroxybenzotriazole (HOBT*H₂O), dicyclohexylcarbodiimide (DCC) / dimethylformamide / 14 h / 0 - 25 °C

2: 98 percent / H₂ / 5percent Pd/C / methanol

3: 86 percent / dicyclohexylcarbodiimide (DCC) / CH₂Cl₂ / 6 h / 0 °C

With 4-methyl-morpholine; hydrogen; benzotriazol-1-ol; dicyclohexyl-carbodiimide; palladium on activated charcoal; In methanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm00359a004

Reference yield:

benzyl (tert-butoxycarbonyl)-L-valyl-L-leucinate (24210-16-0) → Nα-Boc-Val-Leu N-hydroxysuccinimide ester (84642-33-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 98 percent / H₂ / 5percent Pd/C / methanol

2: 86 percent / dicyclohexylcarbodiimide (DCC) / CH₂Cl₂ / 6 h / 0 °C

With hydrogen; dicyclohexyl-carbodiimide; palladium on activated charcoal; In methanol; dichloromethane;

DOI:10.1021/jm00359a004

upstream raw materials:

1-hydroxy-pyrrolidine-2,5-dione

(2S)-2-(2-(tert-butoxycarbonylamino)-3-methylbutanamido)-4-methylpentanoic acid

t-Boc-L-valine

benzyl (tert-butoxycarbonyl)-L-valyl-L-leucinate

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