CarbaMic acid, N-[[4-(2-propyn-1-yloxy)phenyl]Methyl]-, 1,1-diMethylethyl ester

Base Information

• Chemical Name: CarbaMic acid, N-[[4-(2-propyn-1-yloxy)phenyl]Methyl]-, 1,1-diMethylethyl ester
• CAS No.: 1380401-33-1
• Molecular Formula: C15H19NO3
• Molecular Weight: 261.31626
• Mol file: 1380401-33-1.mol

Synonyms:CarbaMic acid, N-[[4-(2-propyn-1-yloxy)phenyl]Methyl]-, 1,1-diMethylethyl ester

Chemical Property of CarbaMic acid, N-[[4-(2-propyn-1-yloxy)phenyl]Methyl]-, 1,1-diMethylethyl ester

Chemical Property:

Purity/Quality:

≥95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of CarbaMic acid, N-[[4-(2-propyn-1-yloxy)phenyl]Methyl]-, 1,1-diMethylethyl ester

There total 5 articles about CarbaMic acid, N-[[4-(2-propyn-1-yloxy)phenyl]Methyl]-, 1,1-diMethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

(4-(prop-2-yn-1-yloxy)phenyl)methanamine (943026-55-9) + di-tert-butyl dicarbonate (24424-99-5) → tert-butyl N-{[4-(prop-2-yn-1-yloxy)phenyl]methyl}carbamate (1380401-33-1)

Guidance literature:

With sodium hydrogencarbonate; In tetrahydrofuran; methanol; water; at 20 ℃;

DOI:10.1002/anie.201201364

Reference yield: 68.0%

propargyl bromide (106-96-7) + tert-butyl (4-hydroxybenzyl)carbamate (149505-94-2) → tert-butyl N-{[4-(prop-2-yn-1-yloxy)phenyl]methyl}carbamate (1380401-33-1)

Guidance literature:

tert-butyl (4-hydroxybenzyl)carbamate; With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; for 0.5h; Inert atmosphere;

propargyl bromide; In N,N-dimethyl-formamide; at 20 ℃; for 12h; Inert atmosphere;

DOI:10.1021/acs.jmedchem.6b01284

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → tert-butyl N-{[4-(prop-2-yn-1-yloxy)phenyl]methyl}carbamate (1380401-33-1)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide / tetrahydrofuran; water / 18 h / 20 °C

2: potassium carbonate / toluene; acetonitrile / 5 h / 70 °C

With potassium carbonate; sodium hydroxide; In tetrahydrofuran; water; toluene; acetonitrile;

DOI:10.1021/ml5001273

upstream raw materials:

(4-(prop-2-yn-1-yloxy)phenyl)methanamine

di-tert-butyl dicarbonate

4-hydroxybenzylamine hydrobromide

propargyl bromide

Downstream raw materials:

C₃₂H₄₆N₄O₄

C₂₇H₃₈N₄O₂

C₃₇H₄₆N₄O₃

(4-(prop-2-yn-1-yloxy)phenyl)methanamine