149505-94-2

Usage

Application

tert-Butyl 4-hydroxybenzylcarbamate is a useful research chemical.

Upstream product

• 2393-23-9 4-methoxy-benzylamine 
• 13139-12-3 tert-butyl 2,5-dioxopyrrolidin-1-yl carbonate 
• 696-60-6 4-aminomethylphenol 
• 34619-03-9 tert-butyldicarbonate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 699-06-9 4-hydroxybenzaldehyde oxime 
• 1004-23-5 4-hydroxy-benzylamine hydrochloride 
• 391668-61-4 tert-butyl (4-(benzyloxy)benzyl)carbamate 
• 90430-14-1 4-hydroxybenzylamine hydrobromide 

Downstream Products

• 775353-65-6 (S)-ethyl 2-(4-((tert-butoxycarbonylamino)methyl)phenoxy)-3-methylbutanoate 
• 775353-66-7 (R)-ethyl 2-(4-((tert-butoxycarbonylamino)methyl)phenoxy)-3-methylbutanoate 
• 118618-46-5 ethyl 2--propionate 
• 775354-28-4 2-(4-aminomethyl-phenoxy)-butyric acid ethyl ester 
• 775354-30-8 2-(4-aminomethyl-phenoxy)-3-methyl-butyric acid ethyl ester 
• 775354-29-5 2-(4-aminomethyl-phenoxy)-pentanoic acid ethyl ester 
• 479586-28-2 (S)-2-(4-Aminomethyl-phenoxy)-3-methyl-butyric acid ethyl ester 
• 1041629-67-7 (R)-2-(4-Aminomethyl-phenoxy)-3-methyl-butyric acid ethyl ester 
• 775354-31-9 2-(4-aminomethyl-phenoxy)-hexanoic acid ethyl ester 
• 775354-32-0 2-(4-{[((S)-Pyrrolidine-2-carbonyl)-amino]-methyl}-phenoxy)-propionic acid ethyl ester 

Relevant academic research and scientific papers

Artificial Macrocycles as Potent p53-MDM2 Inhibitors

Based on a combination of an Ugi four component reaction and a ring closing metathesis, a library of novel artificial macrocyclic inhibitors of the p53-MDM2 interaction was designed and synthesized. These macrocycles, alternatively to stapled peptides, target for the first time the large hydrophobic surface area formed by Tyr67, Gln72, His73, Val93, and Lys94 yielding derivatives with affinity to MDM2 in the nanomolar range. Their binding affinity with MDM2 was evaluated using fluorescence polarization (FP) assay and 1H-15N two-dimensional HSQC nuclear magnetic resonance experiments.

Dual Targeting of Norepinephrine Transporter (NET) Function and Thyrointegrin αvβ3 Receptors in the Treatment of Neuroblastoma

Therapeutic targeting of the norepinephrine transporter (NET) function with benzylguanidine (BG), conjugated with the high-affinity thyrointegrin αvβ3 antagonist triazole tetraiodothyroacetic acid, TAT, via noncleavable bonding to poly(ethylene glycol) (PEG400) (P) might allow for effective treatment options in neuroblastoma. BG-P-TAT is a dual-targeting agent, targeting the NET function and the thyrointegrin αvβ3 receptors that are overexpressed in neuroblastoma and other neuroendocrine tumors. Various cancer cells and actively dividing tumor-endothelial cells express the thyrointegrin αvβ3 receptors. In this work, the novel compound BG-P-TAT was synthesized and evaluated in the neuroblastoma SK-N-FI cell line for improved targeting and to offer a new strategy for patients with neuroblastoma. BG-P-TAT demonstrated significant suppression of neuroblastoma tumor progression, growth, and viability in a dose-dependent manner. In conclusion, BG-P-TAT represents a potential lead candidate for the treatment of neuroblastoma and other neuroendocrine tumors.

Synthesis of novel 2-pyrrolidinone and pyrrolidine derivatives and study of their inhibitory activity against autotaxin enzyme

Autotaxin (ATX), a glycoprotein (~125 kDa) isolated as an autocrine motility factor from melanoma cells, belongs to a seven-membered family of ectonucleotide pyrophosphatase/phosphodiesterase (ENPP), and exhibits lysophospholipase D activity. ATX is responsible for the hydrolysis of lysophosphatidylcholine (LPC) to produce the bioactive lipid lysophosphatidic acid (LPA), which is upregulated in a variety of pathological inflammatory conditions, including fibrosis, cancer, liver toxicity and thrombosis. Given its role in human disease, the ATX-LPA axis is an interesting target for therapy, and the development of novel potent ATX inhibitors is of great importance. In the present work a novel class of ATX inhibitors, optically active derivatives of 2-pyrrolidinone and pyrrolidine heterocycles were synthesized. Some of them exhibited interesting in vitro activity, namely the hydroxamic acid 16 (IC50 700 nM) and the carboxylic acid 40b (IC50 800 nM), while the boronic acid derivatives 3k (IC50 50 nM), 3l (IC50 120 nM), 3 m (IC50 180 nM) and 21 (IC50 35 nM) were found to be potent inhibitors of ATX.

Efficient oxidative self-coupling of polystyrene bearing chain-end primary amines

A series of well-defined linear polystyrenes (PSs) with different degree of polymerization (DP) was synthesized via atom transfer radical polymerization (ATRP) using tert-butyloxycarbonyl (t-boc)-protected 4-(aminomethyl)phenyl 2-bromoisobutyrate (BAPB) a

Diarylcarbonates are a new class of deubiquitinating enzyme inhibitor

Promiscuous inhibitors of tyrosine protein kinases, proteases and phosphatases are useful reagents for probing regulatory pathways and stabilizing lysates as well as starting points for the design of more selective agents. Ubiquitination regulates many cr

Novel derivatives of urea and use thereof

The present invention relates to a novel urea derivative compound and 5HT thereof. 2A The present invention relates to the use of antagonists as antagonists for the prevention or treatment of neuropsychiatric disorders, degenerative brain diseases, propagated disorders and/or metabolic diseases.

Heptamethine indocyanine dye as well as preparation method and application thereof

The invention provides a heptamethine indocyanine dye as well as a preparation method and an application thereof, and belongs to the technical field of fine chemical engineering. The heptamethine indocyanine dye provided by the invention has a structure a

Design, synthesis, and biological evaluation of novel bifunctional thyrointegrin antagonists for neuroblastoma

Receptor-mediated cancer therapy has received much attention in the last few decades. Neuroblastoma and other cancers of the sympathetic nervous system highly express norepinephrine transporter (NET) and cell plasma membrane integrin αvβ3. Dual targeting

Rapid and High-Yield Synthesis of [23]Crown Ether: Applied as a Wheel Component in the Formation of Pseudo[2]rotaxane and Synthesis of [2]Catenane with a Dibenzylammonium Dumbbell

A facile, rapid, and high yield synthesis of [23]crown ether (X23C7) has been developed from commercially available starting materials, in one step with good to excellent yield. The reaction is completed in 6 h under room temperature conditions, with the highest yield being 81%. The X23C7 macrocycle formed pseudo[2]rotaxane with a dibenzylammonium ion (DBA+) dumbbell, exhibiting strong association (Ka = 2.61 × 103 M-1). Consequently, a [2]catenane was synthesized from a DBA+-based diolefin terminated salt and X23C7 in 81% yield, using a threading-followed-ring-closing-metathesis approach.

Discovery of dual targeting PEGylated BG-P1600-TAT to norepinephrine transporter (NET) and thyrointegrin αvβ3 in the treatment of neuroblastoma

Polymer-drug conjugates are growing in interest as novel anticancer agents for targeted cancer therapy. The aim of this study was to synthesize a poly(ethylene glycol) (PEG) conjugated anticancer drug for neuroblastoma, which is the most common extracrani