2-Thiazolecarboxylic acid, 4-[5-broMo-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]-, ethyl ester

Base Information

Chemical Name:2-Thiazolecarboxylic acid, 4-[5-broMo-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]-, ethyl ester
CAS No.:1046793-41-2
Molecular Formula:C19H14BrN3O4S2
Molecular Weight:492.374
Hs Code.:
Mol file:1046793-41-2.mol

Synonyms:2-Thiazolecarboxylic acid, 4-[5-broMo-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]-, ethyl ester;4-(1-benzenesulfonyl-5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)-thiazole-2-carboxylic acid ethyl ester

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Chemical Property of 2-Thiazolecarboxylic acid, 4-[5-broMo-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]-, ethyl ester

Chemical Property:

PSA：127.77000
LogP:5.41680

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 2-Thiazolecarboxylic acid, 4-[5-broMo-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]-, ethyl ester

There total 2 articles about 2-Thiazolecarboxylic acid, 4-[5-broMo-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 1046793-71-8
4-(5-Bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)-thiazole-2-carboxylic acid ethyl ester

: 98-09-9
benzenesulfonyl chloride

: 1046793-41-2
4-(1-Benzenesulfonyl-5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)-thiazole-2-carboxylic acid ethyl ester

Guidance literature:: With sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate; In dichloromethane; water; at 20 ℃; for 1.5h;

Reference yield: 57.0%

: 4-(5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)-thiazole-2-carboxylic acid ethyl ester hydrobromide

: 98-09-9
benzenesulfonyl chloride

: 1046793-41-2
4-(1-Benzenesulfonyl-5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)-thiazole-2-carboxylic acid ethyl ester

Guidance literature:: With sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate; In dichloromethane; water;

Reference yield: 85.0%

: 1046793-41-2
4-(1-Benzenesulfonyl-5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)-thiazole-2-carboxylic acid ethyl ester

: 14559-88-7
2,2-dimethylethenylboronic acid

: 4-[1-Benzenesulfonyl-5-(2-methyl-propenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]-thiazole-2-carboxylic acid ethyl ester

Guidance literature:: With sodium carbonate; lithium chloride; bis-triphenylphosphine-palladium(II) chloride; In ethanol; water; toluene; at 110 ℃; for 1.5h; Heating / reflux;